Abstract Thioredoxins (Trxs), glutaredoxins (Grxs), and peroxiredoxins (Prxs) have been
characterized as electron donors, guards of the intracellular redox state, and “antioxidants” …

The lens of the eye has long been considered as a radiosensitive tissue, but recent research
has suggested that the radiosensitivity is even greater than previously thought. The 2012 …

The ocular lens has a very high content of the antioxidant glutathione (GSH) and the
enzymes that can recycle its oxidized form, glutathione disulfide (GSSG), for further use. It …

Lens opacification or cataract reduces vision in over 80 million people worldwide and blinds
18 million. These numbers will increase dramatically as both the size of the elderly …

The human body harbors within it an intricate and delicate balance between oxidants and
antioxidants. Any disruption in this checks‐and‐balances system can lead to harmful …

Glutaredoxin belongs to the oxidoreductase family, with cytosolic glutaredoxin 1 (Grx1) and
mitochondrial glutaredoxin 2 (Grx2) isoforms. Of the two isozymes, the function of Grx2 is not …

Purpose.: To study the effect of age on the morphologic and biochemical alterations induced
by in vivo exposure of ultraviolet radiation (UV). Methods.: Young and old C57BL/6 mice …

Significance: Reactive oxygen and nitrogen species contributing to homeostatic regulation
and the pathogenesis of various cardiovascular diseases, including atherosclerosis …

[Frontiers in Bioscience E4, 141-155, January 1, 2012] 141 Oxidative stress defense and repair
systems of the ocular lens Lisa A Page 1 [Frontiers in Bioscience E4, 141-155, January 1 …

Aging is a complex process that affects every major system at the molecular, cellular and
organ levels. Although the exact cause of aging is unknown, there is significant evidence …