Recent genomic analyses of metastatic prostate cancer have provided important insight into
adaptive changes in androgen receptor (AR) signaling that underpin resistance to androgen …

The present study aimed to investigate whether ginsenoside Rb1 (G‑Rb1) attenuates spinal
cord injury‑associated oxidative stress in rats by regulating the endothelial nitric oxide …

Simple Summary There is a widespread push toward more biologically relevant pre-clinical
models of prostate cancer that can improve the discovery and translation of new drugs and …

Abstract Background Inhibition of Hsp90 is desirable due to potential downregulation of
oncogenic clients. Early generation inhibitors bind to the N-terminal domain (NTD) but C …

In the context of our SAR study concerning 6BrCaQ analogues as C-terminal Hsp90
inhibitors, we designed and synthesized a novel series of 3-(heteroaryl) quinolin-2 (1 H), of …

Inhibition of the heat shock protein 90 (Hsp90) chaperone is a promising therapeutic
strategy to target expression of the androgen receptor (AR) and other oncogenic drivers in …

We report the first total synthesis of the reported structure of the heat shock protein
expression inhibitor stresgenin B. The synthesis features (1) diastereoselective cyanation of …

The 90-kDa heat shock protein (Hsp90) is a homodimeric molecular chaperone with ATPase
activity, which has become an intensely studied target for the development of drugs for the …

The molecular chaperone heat shock protein 90 (HSP90) works in concert with co-
chaperones to stabilize its client proteins, which include multiple drivers of oncogenesis and …

Inhibition of the heat shock protein 90 (Hsp90) chaperone is a promising therapeutic
strategy to target expression of the androgen receptor (AR) and other oncogenic drivers in …