Immunotoxic effects of environmental pollutants in marine mammals

JPW Desforges, C Sonne, M Levin, U Siebert… - Environment …, 2016 - Elsevier
Due to their marine ecology and life-history, marine mammals accumulate some of the
highest levels of environmental contaminants of all wildlife. Given the increasing prevalence …

Toward a unified approach to dose–response modeling in ecotoxicology

C Ritz - Environmental Toxicology and Chemistry, 2010 - Wiley Online Library
This study reviews dose–response models that are used in ecotoxicology. The focus lies on
clarification of differences and similarities between models, and as a side effect, their …

Network medicine framework for identifying drug-repurposing opportunities for COVID-19

D Morselli Gysi, Í Do Valle, M Zitnik… - Proceedings of the …, 2021 - National Acad Sciences
The COVID-19 pandemic has highlighted the need to quickly and reliably prioritize clinically
approved compounds for their potential effectiveness for severe acute respiratory syndrome …

Dose-response analysis using R

C Ritz, F Baty, JC Streibig, D Gerhard - PloS one, 2015 - journals.plos.org
Dose-response analysis can be carried out using multi-purpose commercial statistical
software, but except for a few special cases the analysis easily becomes cumbersome as …

[HTML][HTML] Searching for drug synergy in complex dose–response landscapes using an interaction potency model

B Yadav, K Wennerberg, T Aittokallio, J Tang - … and structural biotechnology …, 2015 - Elsevier
Rational design of multi-targeted drug combinations is a promising strategy to tackle the
drug resistance problem for many complex disorders. A drug combination is usually …

ColonyArea: an ImageJ plugin to automatically quantify colony formation in clonogenic assays

C Guzman, M Bagga, A Kaur, J Westermarck… - PloS one, 2014 - journals.plos.org
The clonogenic or colony formation assay is a widely used method to study the number and
size of cancer cell colonies that remain after irradiation or cytotoxic agent administration and …

Stability of Middle East respiratory syndrome coronavirus (MERS-CoV) under different environmental conditions

N Van Doremalen, T Bushmaker… - …, 2013 - eurosurveillance.org
The stability of Middle East respiratory syndrome coronavirus (MERS-CoV) was determined
at 20° C-40% relative humidity (RH); 30° C-30% RH and 30° C-80% RH. MERS-CoV was …

Nonlinear regression models and applications in agricultural research

SV Archontoulis, FE Miguez - Agronomy Journal, 2015 - Wiley Online Library
Nonlinear regression models are important tools because many crop and soil processes are
better represented by nonlinear than linear models. Fitting nonlinear models is not a single …

Orthotopic patient-derived xenografts of paediatric solid tumours

E Stewart, SM Federico, X Chen, AA Shelat, C Bradley… - Nature, 2017 - nature.com
Paediatric solid tumours arise from endodermal, ectodermal, or mesodermal lineages.
Although the overall survival of children with solid tumours is 75%, that of children with …

Cover crops support ecological intensification of arable cropping systems

RA Wittwer, B Dorn, W Jossi, MGA Van der Heijden - Scientific reports, 2017 - nature.com
A major challenge for agriculture is to enhance productivity with minimum impact on the
environment. Several studies indicate that cover crops could replace anthropogenic inputs …