Many human phenotypes are impossible to recapitulate in model organisms or immortalized
human cell lines. Induced pluripotent stem cells (iPSCs) offer a way to study disease …

Complex brain disorders are highly heritable and arise from a complex polygenic risk
architecture. Many disease-associated loci are found in non-coding regions that house …

Hydrocephalus, characterized by cerebral ventricular dilatation, is routinely attributed to
primary defects in cerebrospinal fluid (CSF) homeostasis. This fosters CSF shunting as the …

The hippocampus formation, although prominently implicated in schizophrenia
pathogenesis, has been overlooked in large-scale genomics efforts in the schizophrenic …

Specific cell populations may have unique contributions to schizophrenia but may be missed
in studies of homogenate tissue. Here laser capture microdissection followed by RNA …

Mutations in the MECP2 gene underlie a spectrum of neurodevelopmental disorders, most
commonly Rett syndrome (RTT). We ask whether MECP2 mutations interfere with human …

Neurons derived from human induced pluripotent stem cells (hiPSCs) have been used to
model basic cellular aspects of neuropsychiatric disorders, but the relationship between the …

Although splicing occurs largely co-transcriptionally, the order by which introns are removed
does not necessarily follow the order in which they are transcribed. Whereas several …

ELAV/Hu factors are conserved RNA binding proteins (RBPs) that play diverse roles in
mRNA processing and regulation. The founding member, Drosophila Elav, was recognized …

The cellular complexity of the human brain is established via dynamic changes in gene
expression throughout development that is mediated, in part, by the spatiotemporal activity …