Vaccine adjuvants: Understanding the structure and mechanism of adjuvanticity

S Shi, H Zhu, X Xia, Z Liang, X Ma, B Sun - Vaccine, 2019 - Elsevier
In conjugate, inactivated, recombinant, and toxoid vaccines, adjuvants are extensively and
essentially used for enhanced and long-lasting protective immune responses. Depending …

[HTML][HTML] Key roles of adjuvants in modern vaccines

SG Reed, MT Orr, CB Fox - Nature medicine, 2013 - nature.com
Vaccines containing novel adjuvant formulations are increasingly reaching advanced
development and licensing stages, providing new tools to fill previously unmet clinical …

Nanocarriers for skin applications: where do we stand?

N Tiwari, ER Osorio‐Blanco, A Sonzogni… - Angewandte Chemie …, 2022 - Wiley Online Library
Skin penetration of active molecules for treatment of diverse diseases is a major field of
research owing to the advantages associated with the skin like easy accessibility, reduced …

Virus-like particles as a highly efficient vaccine platform: diversity of targets and production systems and advances in clinical development

N Kushnir, SJ Streatfield, V Yusibov - Vaccine, 2012 - Elsevier
Virus-like particles (VLPs) are a class of subunit vaccines that differentiate themselves from
soluble recombinant antigens by stronger protective immunogenicity associated with the …

[HTML][HTML] Vaccine instability in the cold chain: mechanisms, analysis and formulation strategies

OS Kumru, SB Joshi, DE Smith, CR Middaugh, T Prusik… - Biologicals, 2014 - Elsevier
Instability of vaccines often emerges as a key challenge during clinical development (lab to
clinic) as well as commercial distribution (factory to patient). To yield stable, efficacious …

Vaccine technologies: From whole organisms to rationally designed protein assemblies

CP Karch, P Burkhard - Biochemical pharmacology, 2016 - Elsevier
Vaccines have been the single most significant advancement in public health, preventing
morbidity and mortality in millions of people annually. Vaccine development has traditionally …

Intranasal vaccine: Factors to consider in research and development

H Xu, L Cai, S Hufnagel, Z Cui - International journal of pharmaceutics, 2021 - Elsevier
Most existing vaccines for human use are administered by needle-based injection.
Administering vaccines needle-free intranasally has numerous advantages over by needle …

Developments in vaccine adjuvants

FZ Firdaus, M Skwarczynski, I Toth - Vaccine Design: Methods and …, 2022 - Springer
Vaccines, including subunit, recombinant, and conjugate vaccines, require the use of an
immunostimulator/adjuvant for maximum efficacy. Adjuvants not only enhance the strength …

An overview of nanocarrier-based adjuvants for vaccine delivery

KC Petkar, SM Patil, SS Chavhan, K Kaneko… - Pharmaceutics, 2021 - mdpi.com
The development of vaccines is one of the most significant medical accomplishments which
has helped to eradicate a large number of diseases. It has undergone an evolutionary …

Toward precision adjuvants: optimizing science and safety

E Nanishi, DJ Dowling, O Levy - Current opinion in pediatrics, 2020 - journals.lww.com
Toward precision adjuvants: optimizing science and safety : Current Opinion in Pediatrics
Toward precision adjuvants: optimizing science and safety : Current Opinion in Pediatrics Log …