An overview on target-based drug design against kinetoplastid protozoan infections: Human African trypanosomiasis, Chagas disease and leishmaniases

V Kourbeli, E Chontzopoulou, K Moschovou, D Pavlos… - Molecules, 2021 - mdpi.com
The protozoan diseases Human African Trypanosomiasis (HAT), Chagas disease (CD), and
leishmaniases span worldwide and therefore their impact is a universal concern. The …

[HTML][HTML] Visceral leishmaniasis: a global overview

RG Wamai, J Kahn, J McGloin, G Ziaggi - Journal of Global Health …, 2020 - e-jghs.org
The leishmaniases are protozoan infections that are among the neglected tropical diseases
(NTDs). Over one billion people are at risk of these diseases in virtually all continents. These …

Multifunctional organometallic compounds for the treatment of Chagas disease: Re (i) tricarbonyl compounds with two different bioactive ligands

M Soba, G Scalese, F Casuriaga, N Pérez… - Dalton …, 2023 - pubs.rsc.org
Chagas' disease (American Trypanosomiasis) is an ancient and endemic illness in Latin
America caused by the protozoan parasite Trypanosoma cruzi. Although there is an urgent …

Neglected tropical diseases in Brazil: lack of correlation between disease burden, research funding and output

BP Fonseca, PC Albuquerque… - Tropical medicine & …, 2020 - Wiley Online Library
Objectives To assess the correlation between the burden of seven priority neglected tropical
diseases (NTDs) included in the Brazilian National Agenda of Priorities in Health Research …

Metallomics and other omics approaches in antiparasitic metal-based drug research

G Scalese, K Kostenkova, DC Crans… - Current opinion in …, 2022 - Elsevier
Potential use of metal complexes in medicine is an area of bioinorganic chemistry that has
gained much interest. High-throughput omics approaches can provide in-depth insights into …

Recent progress in the development of indole-based compounds active against malaria, trypanosomiasis and leishmaniasis

PAF Pacheco, MMM Santos - Molecules, 2022 - mdpi.com
Human protozoan diseases represent a serious health problem worldwide, affecting mainly
people in social and economic vulnerability. These diseases have attracted little investment …

Neglected tropical diseases and systemic racism especially in Brazil: from socio-economic aspects to the development of new drugs

JR da Conceição, CPG Lopes, EI Ferreira, S Epiphanio… - Acta Tropica, 2022 - Elsevier
Neglected tropical diseases (NTDs) are highly prevalent communicable diseases in tropical
and subtropical countries, generally not economically attractive for drug development and …

Bestatin analogs-4-quinolinone hybrids as antileishmanial hits: Design, repurposing rational, synthesis, in vitro and in silico studies

AHE Hassan, K Mahmoud, TN Phan… - European Journal of …, 2023 - Elsevier
Amongst different forms of leishmaniasis, visceral leishmaniasis caused by L. donovani is
highly mortal. Identification of new hit compounds might afford new starting points to develop …

Facing diseases caused by trypanosomatid parasites: rational design of Pd and Pt complexes with bioactive ligands

D Gambino, L Otero - Frontiers in Chemistry, 2022 - frontiersin.org
Human African Trypanosomiasis (HAT), Chagas disease or American Trypanosomiasis
(CD), and leishmaniases are protozoan infections produced by trypanosomatid parasites …

Marine alkaloids as bioactive agents against protozoal neglected tropical diseases and malaria

AG Tempone, P Pieper, SET Borborema… - Natural product …, 2021 - pubs.rsc.org
Covering: 2000 up to 2021 Natural products are an important resource in drug discovery,
directly or indirectly delivering numerous small molecules for potential development as …