Rho GTPase signaling complexes in cell migration and invasion
CD Lawson, AJ Ridley - Journal of Cell Biology, 2018 - rupress.org
Cell migration is dependent on the dynamic formation and disassembly of actin filament–
based structures, including lamellipodia, filopodia, invadopodia, and membrane blebs, as …
based structures, including lamellipodia, filopodia, invadopodia, and membrane blebs, as …
[HTML][HTML] Fixing the GAP: The role of RhoGAPs in cancer
G Kreider-Letterman, NM Carr… - European journal of cell …, 2022 - Elsevier
Cancer progression and metastasis are processes that involve significant cellular changes.
Many of these changes include alterations in the activity of the Rho GTPase family of …
Many of these changes include alterations in the activity of the Rho GTPase family of …
HNRNPL circularizes ARHGAP35 to produce an oncogenic protein
Y Li, B Chen, J Zhao, Q Li, S Chen, T Guo… - Advanced …, 2021 - Wiley Online Library
Circular RNAs (circRNAs) are an intriguing class of widely prevalent endogenous RNAs, the
vast majority of which have not been characterized functionally. Here, we identified a novel …
vast majority of which have not been characterized functionally. Here, we identified a novel …
p190RhoGAPs, the ARHGAP35- and ARHGAP5-Encoded Proteins, in Health and Disease
C Héraud, M Pinault, V Lagrée, V Moreau - Cells, 2019 - mdpi.com
Small guanosine triphosphatases (GTPases) gathered in the Rat sarcoma (Ras) superfamily
represent a large family of proteins involved in several key cellular mechanisms. Within the …
represent a large family of proteins involved in several key cellular mechanisms. Within the …
Ras superfamily GTPase activating proteins in cancer: Potential therapeutic targets?
H Xiao, G Wang, M Zhao, W Shuai, L Ouyang… - European Journal of …, 2023 - Elsevier
To search more therapeutic strategies for Ras-mutant tumors, regulators of the Ras
superfamily involved in the GTP/GDP (guanosine triphosphate/guanosine diphosphate) …
superfamily involved in the GTP/GDP (guanosine triphosphate/guanosine diphosphate) …
Genomic comparison of endometrioid endometrial carcinoma and its precancerous lesions in Chinese patients by high-depth next generation sequencing
Y Wang, M Yu, JX Yang, DY Cao, Y Zhang… - Frontiers in …, 2019 - frontiersin.org
Endometrial intraepithelial neoplasia (EIN), also known as endometrial atypical hyperplasia
(EAH) is believed to be the precursor lesion of endometrioid endometrial carcinoma (EEC) …
(EAH) is believed to be the precursor lesion of endometrioid endometrial carcinoma (EEC) …
Tandem engagement of phosphotyrosines by the dual SH2 domains of p120RasGAP
Summary p120RasGAP is a multidomain GTPase-activating protein for Ras. The presence
of two Src homology 2 domains in an SH2-SH3-SH2 module raises the possibility that …
of two Src homology 2 domains in an SH2-SH3-SH2 module raises the possibility that …
Analysis of KLF4 regulated genes in cancer cells reveals a role of DNA methylation in promoter-enhancer interactions
Recent studies have revealed an unexpected role of DNA methylation at promoter regions in
transcription activation. However, whether DNA methylation at enhancer regions activates …
transcription activation. However, whether DNA methylation at enhancer regions activates …
Discovery of 2, 5-diaminopyrimidine derivatives as the first series of selective monomeric degraders of B-lymphoid tyrosine kinase
T Fu, Y Zuo, G Xue, D Zhou, Z Pan - European Journal of Medicinal …, 2023 - Elsevier
B-lymphoid tyrosine kinase (BLK) is an important knot of B cell receptor signaling, and
regulates the function and development of B cells subset. Dysfunction of BLK is correlated …
regulates the function and development of B cells subset. Dysfunction of BLK is correlated …
[PDF][PDF] B 淋巴酪氨酸激酶的研究进展
倪佳俐， 侯亚义， 窦环 - 生命科学, 2021 - lifescience.sinh.ac.cn
B 淋巴酪氨酸激酶(BLK) 是SRC 激酶家族成员之一, 具有酪氨酸蛋白激酶活性. BLK
作为“中间分子” 参与免疫细胞发育, 迁移和增殖等生理过程中的信号转导; 在疾病进程中, BLK …
作为“中间分子” 参与免疫细胞发育, 迁移和增殖等生理过程中的信号转导; 在疾病进程中, BLK …