Macrolide antibiotics inhibit protein synthesis by targeting the bacterial ribosome. They bind
at the nascent peptide exit tunnel and partially occlude it. Thus, macrolides have been …

Macrolide resistance mechanisms can be target-based with a change in a 23S ribosomal
RNA (rRNA) residue or a mutation in ribosomal protein L4 or L22 affecting the ribosome's …

The quality of diffraction data obtained using silver and molybdenum microsources has been
compared for six model compounds with a wide range of absorption factors. The …

Aminoglycosides are chemically diverse, broad-spectrum antibiotics that target functional
centers within the bacterial ribosome to impact all four principle stages (initiation, elongation …

Co-translational protein folding is an essential process by which cells ensure the safe and
efficient production and assembly of new proteins in their functional native states following …

Marina V. Rodnina is the winner of the 2015 Hans Neurath Award. Abstract The cellular
proteome is shaped by the combined activities of the gene expression and quality control …

Cells utilize transcriptional and posttranscriptional mechanisms to alter gene expression in
response to environmental cues. Gene-specific controls, including changing the translation …

Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a key role in regulating the
levels of plasma low-density lipoprotein cholesterol (LDL-C). Here, we demonstrate that the …

A carefully timed coculture fermentation of Penicillium fuscum and P. camembertii/
clavigerum yielded eight new 16-membered-ring macrolides, berkeleylactones A–H (1, 4, 6 …

Nascent polypeptides can induce ribosome stalling, regulating downstream genes. Stalling
of ErmBL peptide translation in the presence of the macrolide antibiotic erythromycin leads …