Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases

L Abenavoli, AA Izzo, N Milić, C Cicala… - Phytotherapy …, 2018 - Wiley Online Library
Milk thistle (MT; Silybum marianum), a member of the Asteraceae family, is a therapeutic
herb with a 2,000‐year history of use. MT fruits contain a mixture of flavonolignans …

Botanicals and their bioactive phytochemicals for women's health

BM Dietz, A Hajirahimkhan, TL Dunlap… - Pharmacological reviews, 2016 - ASPET
Botanical dietary supplements are increasingly popular for women's health, particularly for
older women. The specific botanicals women take vary as a function of age. Younger …

Common herbal dietary supplement–drug interactions

GN Asher, AH Corbett, RL Hawke - American family physician, 2017 - aafp.org
Nearly 25% of US adults report concurrently taking a prescription medication with a dietary
supplement. Some supplements, such as St. John's wort and goldenseal, are known to …

[HTML][HTML] Silybin and the liver: from basic research to clinical practice

C Loguercio, D Festi - World journal of gastroenterology: WJG, 2011 - ncbi.nlm.nih.gov
Herbal products are increasingly used, mainly in chronic liver disease. Extracts of milk
thistle, Silymarin and silybin, are the most prescribed natural compounds, with different …

Interactions between herbs and conventional drugs: overview of the clinical data

AA Izzo - Medical Principles and Practice, 2012 - karger.com
This article provides an overview of the clinical evidence of interactions between herbal and
conventional medicines. Herbs involved in drug interactions–or that have been evaluated in …

PBPK models for CYP3A4 and P‐gp DDI prediction: a modeling network of rifampicin, itraconazole, clarithromycin, midazolam, alfentanil, and digoxin

N Hanke, S Frechen, D Moj, H Britz… - CPT …, 2018 - Wiley Online Library
According to current US Food and Drug Administration (FDA) and European Medicines
Agency (EMA) guidance documents, physiologically based pharmacokinetic (PBPK) …

The food plant Silybum marianum (L.) Gaertn.: Phytochemistry, Ethnopharmacology and clinical evidence

I Marmouzi, A Bouyahya, SM Ezzat, M El Jemli… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Silybum marianum (L.) Gaertn. or Milk thistle is a
medicinal plant native to Northern Africa, Southern Europe, Southern Russia and Anatolia. It …

Herb–drug interactions: challenges and opportunities for improved predictions

SJ Brantley, AA Argikar, YS Lin, S Nagar… - Drug Metabolism and …, 2014 - ASPET
Supported by a usage history that predates written records and the perception that “natural”
ensures safety, herbal products have increasingly been incorporated into Western health …

Clinical evidence of herbal drugs as perpetrators of pharmacokinetic drug interactions

R Hermann, O von Richter - Planta medica, 2012 - thieme-connect.com
The use of herbal/botanical products, also referred to as complementary and alternative
medicines (CAM), worldwide enjoys increasing popularity. It appears in particular highly …

Pharmacokinetic herb-drug interactions (part 2): drug interactions involving popular botanical dietary supplements and their clinical relevance

BJ Gurley, EK Fifer, Z Gardner - Planta medica, 2012 - thieme-connect.com
In Part 2 of this review, a critical examination of the pertinent scientific literature is
undertaken in order to assess the interaction risk that popular dietary supplements may pose …