Cancer stem cells—origins and biomarkers: perspectives for targeted personalized therapies

L Walcher, AK Kistenmacher, H Suo, R Kitte… - Frontiers in …, 2020 - frontiersin.org
The use of biomarkers in diagnosis, therapy and prognosis has gained increasing interest
over the last decades. In particular, the analysis of biomarkers in cancer patients within the …

The crucial roles of Bmi-1 in cancer: implications in pathogenesis, metastasis, drug resistance, and targeted therapies

J Xu, L Li, P Shi, H Cui, L Yang - International Journal of Molecular …, 2022 - mdpi.com
B-cell-specific Moloney murine leukemia virus integration region 1 (Bmi-1, also known as
RNF51 or PCGF4) is one of the important members of the PcG gene family, and is involved …

Resveratrol contrasts LPA-induced ovarian cancer cell migration and platinum resistance by rescuing hedgehog-mediated autophagy

A Ferraresi, A Esposito, C Girone, L Vallino, A Salwa… - Cells, 2021 - mdpi.com
Background: Ovarian cancer progression and invasiveness are promoted by a range of
soluble factors released by cancer cells and stromal cells within the tumor …

[HTML][HTML] Induction of apoptosis and ferroptosis by a tumor suppressing magnetic field through ROS-mediated DNA damage

LQ Yuan, C Wang, DF Lu, XD Zhao, LH Tan… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Magnetic field (MF) is being used in antitumor treatment; however, the underlying biological
mechanisms remain unclear. In this study, the potency and mechanism of a previously …

An interplay between senescence, apoptosis and autophagy in glioblastoma multiforme—role in pathogenesis and therapeutic perspective

E Pawlowska, J Szczepanska, M Szatkowska… - International journal of …, 2018 - mdpi.com
Autophagy, cellular senescence, programmed cell death and necrosis are key responses of
a cell facing a stress. These effects are partly interconnected, but regulation of their mutual …

[HTML][HTML] The lncRNA DLX6-AS1/miR-16-5p axis regulates autophagy and apoptosis in non-small cell lung cancer: a Boolean model of cell death

S Gupta, DA Silveira, JCM Mombach… - Non-coding RNA …, 2023 - Elsevier
Long non-coding RNA (lncRNA) distal-less homeobox 6 antisense RNA 1 (DLX6-AS1) is
elevated in a variety of cancers, including non-small cell lung cancer (NSCLC) and cervical …

A novel BMI-1 inhibitor QW24 for the treatment of stem-like colorectal cancer

J Wang, Y Xing, Y Wang, Y He, L Wang, S Peng… - Journal of Experimental …, 2019 - Springer
Background Cancer-initiating cell (CIC), a functionally homogeneous stem-like cell
population, is resonsible for driving the tumor maintenance and metastasis, and is a source …

BMI1 and PTEN are key determinants of breast cancer therapy: A plausible therapeutic target in breast cancer

S Vaishnave - Gene, 2018 - Elsevier
Abstract BMI-1 (B-lymphoma Mo-MLV insertion region 1) is a key protein partner in
polycomb repressive complex 1 (PRC1) that helps in maintaining the integrity of the …

Umbelliprenin improved anti-proliferative effects of ionizing radiation on adult T-cell leukemia/lymphoma cells via interaction with CDK6; an in vitro and in silico study

K Ebrahimi, R Bagheri… - International …, 2024 - journals.sagepub.com
Adult T-cell leukemia/lymphoma (ATL) is an aggressive malignancy with poor survival rates.
The efficacy of radiotherapy in ATL needs enhancement with radiosensitizing agents. This …

BMI1-KLF4 axis deficiency improves responses to neoadjuvant concurrent chemoradiotherapy in patients with rectal cancer

YC Hsu, CW Luo, WL Huang, CC Wu, CL Chou… - Radiotherapy and …, 2020 - Elsevier
Purpose Neoadjuvant concurrent chemoradiotherapy (CCRT) is a gold standard treatment
for patients with stage II/III rectal cancer. B-cell-specific Moloney murine leukemia virus …