Impact of age and gender on glioblastoma onset, progression, and management

A Colopi, S Fuda, S Santi, A Onorato, V Cesarini… - Mechanisms of ageing …, 2023 - Elsevier
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, while its
frequency in pediatric patients is 10–15%. For this reason, age is considered one of the …

[HTML][HTML] Clinical trial links oncolytic immunoactivation to survival in glioblastoma

AL Ling, IH Solomon, AM Landivar, H Nakashima… - Nature, 2023 - nature.com
Immunotherapy failures can result from the highly suppressive tumour microenvironment
that characterizes aggressive forms of cancer such as recurrent glioblastoma (rGBM),. Here …

MDM2 Inhibition in the Treatment of Glioblastoma: From Concept to Clinical Investigation

KI Pellot Ortiz, JS Rechberger, LF Nonnenbroich… - Biomedicines, 2023 - mdpi.com
Inhibition of the interaction between MDM2 and p53 has emerged as a promising strategy
for combating cancer, including the treatment of glioblastoma (GBM). Numerous MDM2 …

White matter tract density index prediction model of overall survival in Glioblastoma

A Salvalaggio, L Pini, M Gaiola, A Velco… - JAMA …, 2023 - jamanetwork.com
Importance The prognosis of overall survival (OS) in patients with glioblastoma (GBM) may
depend on the underlying structural connectivity of the brain. Objective To examine the …

Interpretable machine learning model to predict survival days of malignant brain tumor patients

S Rajput, RA Kapdi, MS Raval… - … Learning: Science and …, 2023 - iopscience.iop.org
An artificial intelligence (AI) model's performance is strongly influenced by the input features.
Therefore, it is vital to find the optimal feature set. It is more crucial for the survival prediction …

GenU-Net++: An Automatic Intracranial Brain Tumors Segmentation Algorithm on 3D Image Series with High Performance

Y Zhang, X Liu, S Wa, Y Liu, J Kang, C Lv - Symmetry, 2021 - mdpi.com
Automatic segmentation of intracranial brain tumors in three-dimensional (3D) image series
is critical in screening and diagnosing related diseases. However, there are various …

Regional development of glioblastoma: the anatomical conundrum of cancer biology and its surgical implication

C De Luca, A Virtuoso, M Papa, F Certo… - Cells, 2022 - mdpi.com
Glioblastoma (GBM) are among the most common malignant central nervous system (CNS)
cancers, they are relatively rare. This evidence suggests that the CNS microenvironment is …

Symmetry GAN detection network: an automatic one-stage high-accuracy detection network for various types of lesions on CT images

Y Zhang, S He, S Wa, Z Zong, J Lin, D Fan, J Fu, C Lv - Symmetry, 2022 - mdpi.com
Computed tomography (CT) is the first modern slice-imaging modality. Recent years have
witnessed its widespread application and improvement in detecting and diagnosing related …

Radiogenomic Predictors of Recurrence in Glioblastoma—A Systematic Review

F Corr, D Grimm, B Sass, M Pojskić, JW Bartsch… - Journal of Personalized …, 2022 - mdpi.com
Glioblastoma, as the most aggressive brain tumor, is associated with a poor prognosis and
outcome. To optimize prognosis and clinical therapy decisions, there is an urgent need to …

Advances in Mass Spectrometry of Gangliosides Expressed in Brain Cancers

MR Biricioiu, M Sarbu, R Ica, Ž Vukelić… - International Journal of …, 2024 - mdpi.com
Gangliosides are highly abundant in the human brain where they are involved in major
biological events. In brain cancers, alterations of ganglioside pattern occur, some of which …