The therapeutic properties of plants have been recognised since time immemorial. Many
pathological conditions have been treated using plant-derived medicines. These medicines …

Advances in the technologies and informatics used to generate and process large biological
data sets (omics data) are promoting a critical shift in the study of biomedical sciences. While …

We previously piloted the concept of a Connectivity Map (CMap), whereby genes, drugs,
and disease states are connected by virtue of common gene-expression signatures. Here …

Abstract Knowledge of the underpinnings of cancer initiation, progression and metastasis
has increased exponentially in recent years. Advanced “omics” coupled with machine …

Emerging threats to human health require a concerted effort in search of both preventive and
treatment strategies, placing natural products at the center of efforts to obtain new therapies …

Here we report Digital RNA with pertUrbation of Genes (DRUG-seq), a high-throughput
platform for drug discovery. Pharmaceutical discovery relies on high-throughput screening …

The decreasing cost of genomic technologies has enabled the molecular characterization of
large-scale clinical disease samples and of molecular changes upon drug treatment in …

Mitochondrial toxicity is an important safety endpoint in drug discovery. Models based solely
on chemical structure for predicting mitochondrial toxicity are currently limited in accuracy …

Hepatocellular carcinoma (HCC) is the most common form of primary adult liver cancer. After
nearly a decade with sorafenib as the only approved treatment, multiple new agents have …

Rationale: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and often fatal
disorder. Two US Food and Drug Administration–approved antifibrotic drugs, nintedanib and …