Epigenetic processes are essential for normal development and the maintenance of tissue-
specific gene expression in mammals. Changes in gene expression and malignant cellular …

Abstract NSD1, NSD2, and NSD3 constitute the nuclear receptor-binding SET Domain
(NSD) family of histone 3 lysine 36 (H3K36) methyltransferases. These structurally similar …

Despite some advances in targeted therapeutics of human cancers, curative cancer
treatment still remains a tremendous challenge due to the occurrence of drug resistance. A …

Wnt/β-catenin-mediated signaling is a key pathway regulating tissue growth and
development, and tumorigenesis, and has received increasing attention in recent years. In …

Epigenetic mechanisms such as histone modification play key roles in the pathogenesis of
multiple myeloma (MM). We previously showed that EZH2, a histone H3 lysine 27 (H3K27) …

The histone methyltransferase G9a is well-documented for its implication in neoplastic
growth. However, recent investigations have demonstrated a key involvement of this …

G9a is a lysine methyltransferase that regulates epigenetic modifications, transcription, and
genome organization. However, whether these properties are dependent on one another or …

Histone modifications are key factors in chromatin packaging, and are responsible for gene
regulation during cell fate determination and development. Abnormal alterations in histone …

G9a is a lysine methyltransferase catalyzing the majority of histone H3 mono-and
dimethylation at Lys-9 (H3K9), responsible for transcriptional repression events in …

Psoriasis is a common and recurrent inflammatory skin disease characterized by
inflammatory cells infiltration of the dermis and excessive proliferation, reduced apoptosis …