Insulin resistance is common in individuals with obesity or type 2 diabetes (T2D), in which
circulating insulin levels are frequently increased. Recent epidemiological and clinical …

p27kip1 (p27) is a member of the universal cyclin-dependent kinase inhibitor (CDKI) family.
p27 expression is regulated by cell contact inhibition and by specific growth factors, such as …

Activating mutations in the BRAF kinase gene have recently been reported in human
cancers. The aim of the present study was to determine the frequency of BRAF mutations in …

Context: TSH is the main factor involved in the control of proliferation of thyrocytes. Recently,
a strong relationship between serum TSH and risk of thyroid malignancy has been reported …

Thyroid tumors are about 3 times more frequent in females than in males. Epidemiological
studies suggest that the use of estrogens may contribute to the pathogenesis of thyroid …

Experimental evidence has shown, both in vitro and in animal models, that neoplastic
growth and subsequent metastasis formation depend on the tumor's ability to induce an …

Thyroid carcinomas are the most frequent endocrine malignancies. Among thyroid
carcinomas the most frequent types are the differentiated forms (follicular, papillary or mixed …

Follicular thyroid cancer is the second most common thyroid malignancy. Dietary iodine
content may determine the relative proportion of follicular thyroid cancer and papillary …

The insulin receptor (IR) occurs in two isoforms (IR-A and IR-B) resulting from alternative
splicing of exon 11 of the gene. The IR-A isoform is predominantly expressed in fetal tissues …

Papillary thyroid carcinoma (PTC) is one extracolonic manifestation affecting about 1–2% of
patients with familial adenomatous polyposis (FAP). Ninety-seven patients with FAP …