Medicinal inorganic chemistry offers additional opportunities for the design of therapeutic
agents not accessible to organic compounds. 1− 3 The wide range of coordination numbers …

History shows that metal-based drugs and remedies have been known and used since very
ancient times. For example, silver was employed in the treatment of wounds and ulcers …

The quest for alternative drugs to the well-known cisplatin and its derivatives, which are still
used in more than 50% of the treatment regimes for patients suffering from cancer, is highly …

Carbenes are perhaps the most versatile reactive intermediates in chemistry. Since the
original visions of “methylene” by Dumas 1 in 1835 and a generalization of this vision by Nef …

N-Heterocyclic carbenes (NHCs) are defined as singlet carbenes, in which the divalent
carbenic center is connected directly to at least one nitrogen atom within the heterocycle. 1 …

This tutorial review compiles the advances that have been achieved in using transition metal
complexes containing N-heterocyclic carbene ligands as components for materials …

Highlights•Metal-NHC complexes have their metal centers stabilized under physiological
conditions and can exhibit anticancer activity.•Metal-NHC complexes having new …

Gold (I) complexes such as auranofin have been used for decades to treat symptoms of
rheumatoid arthritis and have also demonstrated a considerable potential as new anticancer …

Gold (I) complexes with a 1, 3-diethylbenzimidazol-2-ylidene N-heterocyclic carbene (NHC)
ligand of the type NHC-Au-L (L=-Cl,-NHC, or-PPh3) were comparatively evaluated as …

N-Heterocyclic carbenes (NHCs) complexes have received a great deal of attention as new
broad-spectrum antimicrobial and anticancer agents, which encourage the biological activity …