Circuits and functions of the lateral habenula in health and in disease

H Hu, Y Cui, Y Yang - Nature Reviews Neuroscience, 2020 - nature.com
The past decade has witnessed exponentially growing interest in the lateral habenula (LHb)
owing to new discoveries relating to its critical role in regulating negatively motivated …

Neural mechanisms of aggression across species

JE Lischinsky, D Lin - Nature neuroscience, 2020 - nature.com
Aggression is a social behavior essential for securing resources and defending oneself and
family. Thanks to its indispensable function in competition and thus survival, aggression …

[PDF][PDF] Responses and functions of dopamine in nucleus accumbens core during social behaviors

B Dai, F Sun, X Tong, Y Ding, A Kuang, T Osakada… - Cell reports, 2022 - cell.com
Social behaviors are among the most important motivated behaviors. How dopamine (DA),
a" reward" signal, releases during social behaviors has been a topic of interest for decades …

Social stress induces neurovascular pathology promoting depression

C Menard, ML Pfau, GE Hodes, V Kana, VX Wang… - Nature …, 2017 - nature.com
Studies suggest that heightened peripheral inflammation contributes to the pathogenesis of
major depressive disorder. We investigated the effect of chronic social defeat stress, a …

An amygdala-to-hypothalamus circuit for social reward

RK Hu, Y Zuo, T Ly, J Wang, P Meera, YE Wu… - Nature …, 2021 - nature.com
Social interactions and relationships are often rewarding, but the neural mechanisms
through which social interaction drives positive experience remain poorly understood. In this …

[PDF][PDF] Neural circuit mechanisms of social behavior

P Chen, W Hong - Neuron, 2018 - cell.com
We live in a world that is largely socially constructed, and we are constantly involved in and
fundamentally influenced by a broad array of complex social interactions. Social behaviors …

Neural mechanism underlying depressive-like state associated with social status loss

Z Fan, J Chang, Y Liang, H Zhu, C Zhang, D Zheng… - Cell, 2023 - cell.com
Downward social mobility is a well-known mental risk factor for depression, but its neural
mechanism remains elusive. Here, by forcing mice to lose against their subordinates in a …

[PDF][PDF] Neural circuits of social behaviors: Innate yet flexible

D Wei, V Talwar, D Lin - Neuron, 2021 - cell.com
Social behaviors, such as mating, fighting, and parenting, are fundamental for survival of any
vertebrate species. All members of a species express social behaviors in a stereotypical and …

[HTML][HTML] Aggression, social stress, and the immune system in humans and animal models

A Takahashi, ME Flanigan, BS McEwen… - Frontiers in Behavioral …, 2018 - frontiersin.org
Social stress can lead to the development of psychological problems ranging from
exaggerated anxiety and depression to antisocial and violence-related behaviors …

Orexin signaling in GABAergic lateral habenula neurons modulates aggressive behavior in male mice

ME Flanigan, H Aleyasin, L Li, CJ Burnett… - Nature …, 2020 - nature.com
Heightened aggression is characteristic of multiple neuropsychiatric disorders and can have
various negative effects on patients, their families and the public. Recent studies in humans …