Recent advances of α-glucosidase inhibitors: A comprehensive review
Background: Diabetes mellitus (DM) is a critical health issue prevailing in nearly half a
billion people worldwide. It is one of the most threatening metabolic diseases. Type 2 DM is …
billion people worldwide. It is one of the most threatening metabolic diseases. Type 2 DM is …
Bio-oriented synthesis of novel polyhydroquinoline derivatives as α-glucosidase inhibitor for management of diabetes
Polyhydroquinoline derivatives (1-15) were synthesized through an unsymmetrical Hantzsch
reaction in excellent yields by treating 3, 5-dibromo-4-hydroxybenzaldehyde, dimedone …
reaction in excellent yields by treating 3, 5-dibromo-4-hydroxybenzaldehyde, dimedone …
Synthesis of new bis (dimethylamino) benzophenone hydrazone for diabetic management: In-vitro and in-silico approach
Inhibiting α-glucosidase is a reliable method for reducing blood sugar levels in diabetic
individuals. Bis (dimethylamino) benzophenone derivatives 1–27 were synthesized from bis …
individuals. Bis (dimethylamino) benzophenone derivatives 1–27 were synthesized from bis …
Anti-α-glucosidase, SAR analysis, and mechanism investigation of indolo [1, 2-b] isoquinoline derivatives
M Li, L Li, L Lu, X Xu, J Hu, JB Peng - Molecules, 2023 - mdpi.com
To find potential α-glucosidase inhibitors, indolo [1, 2-b] isoquinoline derivatives (1–20)
were screened for their α-glucosidase inhibitory effects. All derivatives presented potential α …
were screened for their α-glucosidase inhibitory effects. All derivatives presented potential α …
Novel polyhydroquinoline Schiff's base derivatives: synthesis, characterization, in vitro α-glucosidase inhibitory, and molecular docking studies
N Shahab, D Kong, M Ali, A Alam, N Ur Rehman… - Research on Chemical …, 2023 - Springer
Novel Schiff's base hydrazone derivatives (1–24) based on polyhydroquinoline (PHQ) were
synthesized in good to excellent yields via three step reactions. Compound 1 (starting …
synthesized in good to excellent yields via three step reactions. Compound 1 (starting …
Hybrid quinoline-thiosemicarbazone therapeutics as a new treatment opportunity for Alzheimer's disease‒synthesis, in vitro cholinesterase inhibitory potential and …
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the leading
cause of dementia worldwide. The limited pharmacological approaches based on …
cause of dementia worldwide. The limited pharmacological approaches based on …
Polyhydroquinoline Derivatives for Diabetic Management: Synthesis, in Vitro and in Silico Approaches
F Talab, Zainab, A Alam, M Ali… - Future Medicinal …, 2023 - Taylor & Francis
Background: Medication used to treat Type 2 diabetes by decreasing the absorption of
carbohydrates in the intestine consists of α-glucosidase inhibitors. Polyhydroquinoline …
carbohydrates in the intestine consists of α-glucosidase inhibitors. Polyhydroquinoline …
Synthesis of new diphenyl urea-clubbed imine analogs and its Implications in diabetic management through in vitro and in silico approaches
Type II diabetes mellitus (T2DM) is a global health issue with high rate of prevalence. The
inhibition of α-glucosidase enzyme has prime importance in the management of T2DM. This …
inhibition of α-glucosidase enzyme has prime importance in the management of T2DM. This …
New acetylphenol-based acyl thioureas broaden the scope of drug candidates for urease inhibition: synthesis, in vitro screening and in silico analysis
Helicobacter pylori urease remains a validated drug target for the eradication of pervasive
chronic stomach infection that leads to severe human health diseases such as gastritis and …
chronic stomach infection that leads to severe human health diseases such as gastritis and …
Novel tetrahydrobenzo [b] thiophen-2-yl) urea derivatives as novel α-glucosidase inhibitors: Synthesis, kinetics study, molecular docking, and in vivo anti …
HX Xie, J Zhang, Y Li, JH Zhang, SK Liu, J Zhang… - Bioorganic …, 2021 - Elsevier
Abstract α-Glucosidase inhibitors, which can inhibit the digestion of carbohydrates into
glucose, are one of important groups of anti-type 2 diabetic drugs. In the present study, we …
glucose, are one of important groups of anti-type 2 diabetic drugs. In the present study, we …