BGC Atlas: a web resource for exploring the global chemical diversity encoded in bacterial genomes

C Bağcı, M Nuhamunada, H Goyat… - Nucleic Acids …, 2024 - academic.oup.com
Secondary metabolites are compounds not essential for an organism's development, but
provide significant ecological and physiological benefits. These compounds have …

Protective mechanisms of vaginal lactobacilli against sexually transmitted viral infections

E Avitabile, L Menotti, V Croatti… - International …, 2024 - pmc.ncbi.nlm.nih.gov
The healthy cervicovaginal microbiota is dominated by various Lactobacillus species, which
support a condition of eubiosis. Among their many functions, vaginal lactobacilli contribute to …

The Embodied Microbiome

RR Dietert, JM Dietert - 2023 - preprints.org
Microbes are the most prevalent and widely-distributed life form on planet Earth. They are
also cognitive organisms with memory and superior problem-solving skills that use quantum …

Rule-based omics mining reveals antimicrobial macrocyclic peptides against drug-resistant clinical isolates

Z Cheng, BB He, K Lei, Y Gao, Y Shi, Z Zhong… - Nature …, 2024 - nature.com
Antimicrobial resistance remains a significant global threat, driving up mortality rates
worldwide. Ribosomally synthesized and post-translationally modified peptides have …

Characterization of the probiotic properties of Lacticaseibacillus rhamnosus LR6 isolated from the vaginas of healthy Korean women against vaginal pathogens

Y Chung, SB Kang, D Son, JY Lee, MJ Chung… - Frontiers in …, 2023 - frontiersin.org
The human microbiome exhibits intricate populations across the body, with the vaginal tract
serving as an ecosystem characterized by the prevalence of the genus Lactobacillus …

Prevention and cure of murine C. difficile infection by a Lachnospiraceae strain

JN Tejada, WA Walters, Y Wang, M Kordahi… - Gut …, 2024 - Taylor & Francis
We sought to better understand how intestinal microbiota confer protection against
Clostridioides difficile (C. difficile) infection (CDI). We utilized gnotobiotic altered Schaedler …

Exploring the roles of ribosomal peptides in prokaryote-phage interactions through deep learning-enabled metagenome mining

Y Gao, Z Zhong, D Zhang, J Zhang, YX Li - Microbiome, 2024 - Springer
Background Microbial secondary metabolites play a crucial role in the intricate interactions
within the natural environment. Among these metabolites, ribosomally synthesized and post …

Combinatorial discovery of antibacterials via a feature-fusion based machine learning workflow

C Wang, Y Wu, Y Xue, L Zou, Y Huang, P Zhang… - Chemical Science, 2024 - pubs.rsc.org
The discovery of new antibacterials within the vast chemical space is crucial in combating
drug-resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) …

The composition of Tibetan kefir grain TKG-Y and the antibacterial potential and milk fermentation ability of S. warneri KYS-164 screened from TKG-Y

X Guo, Y He, Y Cheng, J Liang, P Xu, W He, J Che… - Food & Function, 2024 - pubs.rsc.org
This study utilized high-throughput sequencing and SEM observation to elucidate the
microbial composition of a Tibetan herder's homemade kefir grain named TKG-Y …

[HTML][HTML] A molecular view on the interference established between vaginal Lactobacilli and pathogenic Candida species: Challenges and opportunities for the …

NA Pedro, NP Mira - Microbiological Research, 2024 - Elsevier
Vaginal infectious diseases caused by viruses and bacteria have been linked to the
occurrence of dysbiosis, that is, a reduction in the abundance of the normally dominating …