GABA tone regulation and its cognitive functions in the brain

W Koh, H Kwak, E Cheong, CJ Lee - Nature Reviews Neuroscience, 2023 - nature.com
Abstract γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter released at
GABAergic synapses, mediating fast-acting phasic inhibition. Emerging lines of evidence …

GABAergic interneurons in the neocortex: from cellular properties to circuits

R Tremblay, S Lee, B Rudy - Neuron, 2016 - cell.com
Cortical networks are composed of glutamatergic excitatory projection neurons and local
GABAergic inhibitory interneurons that gate signal flow and sculpt network dynamics …

[HTML][HTML] Less is more: expectation sharpens representations in the primary visual cortex

P Kok, JFM Jehee, FP De Lange - Neuron, 2012 - cell.com
Prior expectations about the visual world facilitate perception by allowing us to quickly
deduce plausible interpretations from noisy and ambiguous data. The neural mechanisms of …

Deep cortical layers are activated directly by thalamus

CM Constantinople, RM Bruno - Science, 2013 - science.org
The thalamocortical (TC) projection to layer 4 (L4) is thought to be the main route by which
sensory organs communicate with cortex. Sensory information is believed to then propagate …

Tracking neural activity from the same cells during the entire adult life of mice

S Zhao, X Tang, W Tian, S Partarrieu, R Liu… - Nature …, 2023 - nature.com
Stably recording the electrical activity of the same neurons over the adult life of an animal is
important to neuroscience research and biomedical applications. Current implantable …

Dynamic lateralization of pupil dilation evoked by locus coeruleus activation results from sympathetic, not parasympathetic, contributions

Y Liu, C Rodenkirch, N Moskowitz, B Schriver, Q Wang - Cell reports, 2017 - cell.com
Pupil size is collectively controlled by the sympathetic dilator and parasympathetic sphincter
muscles. Locus coeruleus (LC) activation has been shown to evoke pupil dilation, but how …

[HTML][HTML] Barrel cortex function

D Feldmeyer, M Brecht, F Helmchen… - Progress in …, 2013 - Elsevier
Neocortex, the neuronal structure at the base of the remarkable cognitive skills of mammals,
is a layered sheet of neuronal tissue composed of juxtaposed and interconnected columns …

Moving sensory adaptation beyond suppressive effects in single neurons

SG Solomon, A Kohn - Current biology, 2014 - cell.com
How an object is perceived depends on the temporal context in which it is encountered.
Sensory signals in the brain also depend on temporal context, a phenomenon often referred …

The impact of chronic blood–brain barrier breach on intracortical electrode function

T Saxena, L Karumbaiah, EA Gaupp, R Patkar, K Patil… - Biomaterials, 2013 - Elsevier
Brain-computer interfaces (BCIs) have allowed control of prosthetic limbs in paralyzed
patients. Unfortunately, the electrodes of the BCI that interface with the brain only function for …

Astrocytes control sensory acuity via tonic inhibition in the thalamus

H Kwak, W Koh, S Kim, K Song, JI Shin, JM Lee… - Neuron, 2020 - cell.com
Sensory discrimination is essential for survival. However, how sensory information is finely
controlled in the brain is not well defined. Here, we show that astrocytes control tactile acuity …