Type 2 diabetes mellitus (T2DM) is a chronic, complex metabolic disease characterized by
chronic hyperglycemia causing from insufficient insulin signaling because of insulin …

Insulin resistance (IR) plays a crucial role in the development and progression of
metabolism-related diseases such as diabetes, hypertension, tumors, and nonalcoholic fatty …

Background: Frailty is a multidimensional condition often diagnosed in older adults with
hypertension and diabetes, and both these conditions are associated with endothelial …

Insulin resistance (IR) and cardiovascular disease (CVD) represent two universal public
health hazards, especially in today's Western societies. A causal-effect relationship has …

Diabetes, a complex multisystem metabolic disorder characterized by hyperglycemia, leads
to complications that reduce quality of life and increase mortality. Diabetes pathophysiology …

Summary Sodium-glucose co-transporter 2 (SGLT2) inhibitors, initially developed as a novel
class of anti-hyperglycaemic drugs, have been shown to significantly improve metabolic …

Insulin action in the human brain modulates eating behaviour, whole-body metabolism and
body fat distribution,. In particular, brain insulin action increases whole-body insulin …

BACKGROUND Insulin resistance of the brain can unfavorably affect long-term weight
maintenance and body fat distribution. Little is known if and how brain insulin sensitivity can …

Cognitive impairment is a core feature of schizophrenia, which is aggravated by
antipsychotics-induced metabolic disturbance and lacks effective pharmacologic treatments …

Objective: Based on the 4D label-free phosphoproteomic technique, we examined the
differences in cognitive function and hippocampal phosphorylated protein expression in …