Neuronal cell death mechanisms in major neurodegenerative diseases
Neuronal cell death in the central nervous system has always been a challenging process to
decipher. In normal physiological conditions, neuronal cell death is restricted in the adult …
decipher. In normal physiological conditions, neuronal cell death is restricted in the adult …
[HTML][HTML] Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis
Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are fatal
neurodegenerative disorders that are thought to exist on a clinical and pathological …
neurodegenerative disorders that are thought to exist on a clinical and pathological …
Characterization and biomarker analyses of post-COVID-19 complications and neurological manifestations
As the SARS-CoV-2 pandemic continues, reports have demonstrated neurologic sequelae
following COVID-19 recovery. Mechanisms to explain long-term neurological sequelae are …
following COVID-19 recovery. Mechanisms to explain long-term neurological sequelae are …
Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration
Mitochondrial dysfunction and axon loss are hallmarks of neurologic diseases. Gasdermin
(GSDM) proteins are executioner pore-forming molecules that mediate cell death, yet their …
(GSDM) proteins are executioner pore-forming molecules that mediate cell death, yet their …
[HTML][HTML] p53 is a central regulator driving neurodegeneration caused by C9orf72 poly (PR)
M Maor-Nof, Z Shipony, R Lopez-Gonzalez… - Cell, 2021 - cell.com
The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal
dementia (FTD) is a GGGGCC repeat expansion in the C9orf72 gene. We developed a …
dementia (FTD) is a GGGGCC repeat expansion in the C9orf72 gene. We developed a …
Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology
Abstract Amyotrophic Lateral Sclerosis (ALS) causes motor neuron degeneration, with 97%
of cases exhibiting TDP-43 proteinopathy. Elucidating pathomechanisms has been …
of cases exhibiting TDP-43 proteinopathy. Elucidating pathomechanisms has been …
Brain-trait-associated variants impact cell-type-specific gene regulation during neurogenesis
N Aygün, AL Elwell, D Liang, MJ Lafferty… - The American Journal of …, 2021 - cell.com
Interpretation of the function of non-coding risk loci for neuropsychiatric disorders and brain-
relevant traits via gene expression and alternative splicing quantitative trait locus (e/sQTL) …
relevant traits via gene expression and alternative splicing quantitative trait locus (e/sQTL) …
Transcriptomic analysis of frontotemporal lobar degeneration with TDP-43 pathology reveals cellular alterations across multiple brain regions
R Hasan, J Humphrey, C Bettencourt, J Newcombe… - Acta …, 2022 - Springer
Frontotemporal lobar degeneration (FTLD) is a group of heterogeneous neurodegenerative
disorders affecting the frontal and temporal lobes of the brain. Nuclear loss and cytoplasmic …
disorders affecting the frontal and temporal lobes of the brain. Nuclear loss and cytoplasmic …
Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis
GC Pereira, L Sanchez, PM Schaughency… - Mobile Dna, 2018 - Springer
Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease
involving loss of motor neurons and having no known cure and uncertain etiology. Several …
involving loss of motor neurons and having no known cure and uncertain etiology. Several …
Central synaptopathy is the most conserved feature of motor circuit pathology across spinal muscular atrophy mouse models
JM Buettner, JKS Longang, F Gerstner, KS Apel… - Iscience, 2021 - cell.com
Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by reduced survival
motor neuron (SMN) protein. Recently, SMN dysfunction has been linked to individual …
motor neuron (SMN) protein. Recently, SMN dysfunction has been linked to individual …