In developmental biology, knowledge of cell structure and their (morpho) dynamic behavior,
leads to a comprehensive understanding of their conducts and the mechanisms in which …

Label-free imaging uses inherent contrast mechanisms within cells to create image contrast
without introducing dyes/labels, which may confound results. Quantitative phase imaging is …

Mitochondria display complex morphology and movements, which complicates their
segmentation and tracking in time-lapse images. Here, we introduce Mitometer, an algorithm …

Particle tracking is of key importance for quantitative analysis of intracellular dynamic
processes from time-lapse microscopy image data. Because manually detecting and …

Cell migration is central to the development and maintenance of multicellular organisms.
Fundamental understanding of cell migration can, for example, direct novel therapeutic …

A genome-wide association study identified LMO1, which encodes an LIM-domain-only
transcriptional cofactor, as a neuroblastoma susceptibility gene that functions as an …

Due to the enormous potential and impact that stem cells may have on regenerative
medicine, there has been a rapidly growing interest for tools to analyze and characterize the …

The complexity of cancer biology and its clinical manifestation are driven by genetic,
epigenetic, transcriptomic, proteomic and metabolomic alterations, supported by genomic …

In adaptation to oncogenic signals, pancreatic ductal adenocarcinoma (PDAC) cells
undergo epithelial–mesenchymal transition (EMT), a process combining tumor cell …

Tracking motile cells in time-lapse series is challenging and is required in many biomedical
applications. Cell tracks can be mathematically represented as acyclic oriented graphs …