Ageing organisms accumulate senescent cells that are thought to contribute to body
dysfunction. Telomere shortening and damage are recognized causes of cellular …

Reactive oxygen species (ROS) have been extensively studied as a cause of male infertility.
Excessive levels of ROS coupled with a deficiency in antioxidants can lead to oxidative …

Background Depression is associated with an unusually high rate of aging-related illnesses
and early mortality. One aspect of “accelerated aging” in depression may be shortened …

Telomerase is a ribonucleoprotein that counteracts telomere shortening and can immortalise
human cells. There is also evidence for a telomere-independent survival function of …

Telomeres, the repeated sequences that cap chromosome ends, undergo shortening with
each cell division, and therefore serve as markers of a cell's replicative history. In vivo, clonal …

Multiple molecular, cellular, structural, and functional changes occur in the brain during
aging. Neural cells may respond to these changes adaptively, or they may succumb to …

Cellular senescence is the ultimate and irreversible loss of replicative capacity occurring in
primary somatic cell culture. It is triggered as a stereotypic response to unrepaired nuclear …

Degeneration and death of neurons is the fundamental process responsible for the clinical
manifestations of many different neurological disorders of aging, incuding Alzheimer's …

Once immortalized, human cells are susceptible to transformation by introduction of an
oncogene such as ras. Several lines of evidence now suggest that the maintenance of …

The extremities of eukaryotic chromosomes are called telomeres. They have a structure
unlike the bulk of the chromosome, which allows the cell DNA repair machinery to …