The neural basis of psychedelic action
Psychedelics are serotonin 2A receptor agonists that can lead to profound changes in
perception, cognition and mood. In this review, we focus on the basic neurobiology …
perception, cognition and mood. In this review, we focus on the basic neurobiology …
Adverse effects of psychedelics: From anecdotes and misinformation to systematic science
Background: Despite an increasing body of research highlighting their efficacy to treat a
broad range of medical conditions, psychedelic drugs remain a controversial issue among …
broad range of medical conditions, psychedelic drugs remain a controversial issue among …
[HTML][HTML] Single-dose psilocybin for a treatment-resistant episode of major depression
GM Goodwin, ST Aaronson, O Alvarez… - … England Journal of …, 2022 - Mass Medical Soc
Background Psilocybin is being studied for use in treatment-resistant depression. Methods
In this phase 2 double-blind trial, we randomly assigned adults with treatment-resistant …
In this phase 2 double-blind trial, we randomly assigned adults with treatment-resistant …
Percentage of heavy drinking days following psilocybin-assisted psychotherapy vs placebo in the treatment of adult patients with alcohol use disorder: a randomized …
MP Bogenschutz, S Ross, S Bhatt, T Baron… - JAMA …, 2022 - jamanetwork.com
Importance Although classic psychedelic medications have shown promise in the treatment
of alcohol use disorder (AUD), the efficacy of psilocybin remains unknown. Objective To …
of alcohol use disorder (AUD), the efficacy of psilocybin remains unknown. Objective To …
Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity
There is considerable interest in screening ultralarge chemical libraries for ligand discovery,
both empirically and computationally,,–. Efforts have focused on readily synthesizable …
both empirically and computationally,,–. Efforts have focused on readily synthesizable …
Efficacy and safety of psilocybin-assisted treatment for major depressive disorder: Prospective 12-month follow-up
Background: Preliminary data suggest that psilocybin-assisted treatment produces
substantial and rapid antidepressant effects in patients with major depressive disorder …
substantial and rapid antidepressant effects in patients with major depressive disorder …
[HTML][HTML] Trial of psilocybin versus escitalopram for depression
R Carhart-Harris, B Giribaldi, R Watts… - … England Journal of …, 2021 - Mass Medical Soc
Background Psilocybin may have antidepressant properties, but direct comparisons
between psilocybin and established treatments for depression are lacking. Methods In a …
between psilocybin and established treatments for depression are lacking. Methods In a …
Single-dose psilocybin-assisted therapy in major depressive disorder: a placebo-controlled, double-blind, randomised clinical trial
R von Rotz, EM Schindowski, J Jungwirth… - …, 2023 - thelancet.com
Background Psilocybin has been suggested as a novel, rapid-acting treatment for
depression. Two consecutive doses have been shown to markedly decrease symptom …
depression. Two consecutive doses have been shown to markedly decrease symptom …
Structure-based discovery of nonhallucinogenic psychedelic analogs
D Cao, J Yu, H Wang, Z Luo, X Liu, L He, J Qi, L Fan… - Science, 2022 - science.org
Drugs that target the human serotonin 2A receptor (5-HT2AR) are used to treat
neuropsychiatric diseases; however, many have hallucinogenic effects, hampering their use …
neuropsychiatric diseases; however, many have hallucinogenic effects, hampering their use …
[PDF][PDF] Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo
Psilocybin is a serotonergic psychedelic with untapped therapeutic potential. There are hints
that the use of psychedelics can produce neural adaptations, although the extent and …
that the use of psychedelics can produce neural adaptations, although the extent and …