More than half of human genes use alternative cleavage and polyadenylation to generate
alternative 3′ untranslated region (3′ UTR) isoforms. Most efforts have focused on …

Alternative precursor-mRNA splicing is a key mechanism for regulating gene expression in
mammals and is controlled by specialized RNA-binding proteins. The misregulation of …

The prognosis of cervical patients significantly decreases as the cancer metastasizes to
other parts of the body. The epithelial to mesenchymal transition (EMT) plays an important …

The extracellular-regulated kinases ERK1 and ERK2 are evolutionarily conserved,
ubiquitous serine–threonine kinases that are involved in regulating cellular signaling in both …

RNA-binding proteins (RBPs) are key components in RNA metabolism, regulating the
temporal, spatial and functional dynamics of RNAs. Altering the expression of RBPs has …

Localization of β-actin messenger RNA to sites of active actin polymerization modulates cell
migration during embryogenesis, differentiation and possibly carcinogenesis,,,,. This …

The hnRNP K homology (KH) domain was first identified in the protein human
heterogeneous nuclear ribonucleoprotein K (hnRNP K) 14 years ago. Since then, KH …

Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is a neurodegenerative disorder
caused by expansion of 55–200 CGG repeats in the 5′‐UTR of the FMR1 gene. FXTAS is …

The SWI/SNF (mating-type switch/sucrose nonfermenting) complex involved in chromatin
remodeling on promoters has also been detected on the coding region of genes. Here we …

Obesity is associated with insulin resistance and type 2 diabetes; molecular mechanisms
that promote energy expenditure can be utilized for effective therapy. Src-associated in …