Origins of specificity in protein-DNA recognition
Specific interactions between proteins and DNA are fundamental to many biological
processes. In this review, we provide a revised view of protein-DNA interactions that …
processes. In this review, we provide a revised view of protein-DNA interactions that …
The evolution of transcriptional regulation in eukaryotes
Gene expression is central to the genotype-phenotype relationship in all organisms, and it is
an important component of the genetic basis for evolutionary change in diverse aspects of …
an important component of the genetic basis for evolutionary change in diverse aspects of …
[HTML][HTML] Molecular topography of an entire nervous system
We have produced gene expression profiles of all 302 neurons of the C. elegans nervous
system that match the single-cell resolution of its anatomy and wiring diagram. Our results …
system that match the single-cell resolution of its anatomy and wiring diagram. Our results …
[HTML][HTML] Cofactor binding evokes latent differences in DNA binding specificity between Hox proteins
Members of transcription factor families typically have similar DNA binding specificities yet
execute unique functions in vivo. Transcription factors often bind DNA as multiprotein …
execute unique functions in vivo. Transcription factors often bind DNA as multiprotein …
MyoD and the transcriptional control of myogenesis
CA Berkes, SJ Tapscott - Seminars in cell & developmental biology, 2005 - Elsevier
The basic helix-loop-helix myogenic regulatory factors MyoD, Myf5, myogenin and MRF4
have critical roles in skeletal muscle development. Together with the Mef2 proteins and E …
have critical roles in skeletal muscle development. Together with the Mef2 proteins and E …
Pax-6, a murine paired box gene, is expressed in the developing CNS
C Walther, P Gruss - Development, 1991 - journals.biologists.com
ABSTRACT A multigene family of paired-box-containing genes (Pax genes) has been
identified in the mouse. In this report, we describe the expression pattern of Pax-6 during …
identified in the mouse. In this report, we describe the expression pattern of Pax-6 during …
Homeodomain proteins
WJ Gehring, M Affolter, T Bürglin - Annual review of biochemistry, 1994 - annualreviews.org
Homeotic genes are master control genes that specify the body plan and regulate
development of higher organisms. They share a common sequence element of 180 bp, the …
development of higher organisms. They share a common sequence element of 180 bp, the …
[HTML][HTML] Crx, a novel otx-like homeobox gene, shows photoreceptor-specific expression and regulates photoreceptor differentiation
T Furukawa, EM Morrow, CL Cepko - Cell, 1997 - cell.com
We have isolated a novel otx-like homeobox gene, Crx, from the mouse retina. Crx
expression is restricted to developing and mature photoreceptor cells. CRX bound and …
expression is restricted to developing and mature photoreceptor cells. CRX bound and …
[HTML][HTML] Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences
Most homeodomains are unique within a genome, yet many are highly conserved across
vast evolutionary distances, implying strong selection on their precise DNA-binding …
vast evolutionary distances, implying strong selection on their precise DNA-binding …
Homeodomain-DNA recognition
WJ Gehring, YQ Qian, M Billeter… - Cell, 1994 - Elsevier
Homeodomain-DNA Recognition Review Page 1 Cell, Vol. 79, 211-223, July 29, 1994, Copyright
0 1994 by Cell Press Homeodomain-DNA Recognition Review Waiter J. Gehring; Yan Giu …
0 1994 by Cell Press Homeodomain-DNA Recognition Review Waiter J. Gehring; Yan Giu …