Monkeypox: disease epidemiology, host immunity and clinical interventions
Monkeypox virus (MPXV), which causes disease in humans, has for many years been
restricted to the African continent, with only a handful of sporadic cases in other parts of the …
restricted to the African continent, with only a handful of sporadic cases in other parts of the …
Natural killer cells in cancer biology and therapy
SY Wu, T Fu, YZ Jiang, ZM Shao - Molecular cancer, 2020 - Springer
The tumor microenvironment is highly complex, and immune escape is currently considered
an important hallmark of cancer, largely contributing to tumor progression and metastasis …
an important hallmark of cancer, largely contributing to tumor progression and metastasis …
[HTML][HTML] Anti-NKG2A mAb is a checkpoint inhibitor that promotes anti-tumor immunity by unleashing both T and NK cells
P André, C Denis, C Soulas, C Bourbon-Caillet… - Cell, 2018 - cell.com
Checkpoint inhibitors have revolutionized cancer treatment. However, only a minority of
patients respond to these immunotherapies. Here, we report that blocking the inhibitory …
patients respond to these immunotherapies. Here, we report that blocking the inhibitory …
The molecular mechanism of natural killer cells function and its importance in cancer immunotherapy
S Paul, G Lal - Frontiers in immunology, 2017 - frontiersin.org
Natural killer (NK) cells are innate immune cells that show strong cytolytic function against
physiologically stressed cells such as tumor cells and virus-infected cells. NK cells show a …
physiologically stressed cells such as tumor cells and virus-infected cells. NK cells show a …
LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity
Summary Exhausted CD8 T (T ex) cells in chronic viral infection and cancer have sustained
co-expression of inhibitory receptors (IRs). T ex cells can be reinvigorated by blocking IRs …
co-expression of inhibitory receptors (IRs). T ex cells can be reinvigorated by blocking IRs …
NKG2A blockade potentiates CD8 T cell immunity induced by cancer vaccines
N van Montfoort, L Borst, MJ Korrer, M Sluijter… - Cell, 2018 - cell.com
Tumor-infiltrating CD8 T cells were found to frequently express the inhibitory receptor
NKG2A, particularly in immune-reactive environments and after therapeutic cancer …
NKG2A, particularly in immune-reactive environments and after therapeutic cancer …
NK cell recognition
LL Lanier - Annu. Rev. Immunol., 2005 - annualreviews.org
NK CELL RECOGNITION | Annual Reviews Menu Publications AZ Journal Information About
Subscribe Give Personal Register/Sign-in 0 Cart Help Journal Information Author Resource …
Subscribe Give Personal Register/Sign-in 0 Cart Help Journal Information Author Resource …
Uterine natural killer cells: functional distinctions and influence on pregnancy in humans and mice
Our understanding of development and function of natural killer (NK) cells has progressed
significantly in recent years. However, exactly how uterine NK (uNK) cells develop and …
significantly in recent years. However, exactly how uterine NK (uNK) cells develop and …
Imprint of human cytomegalovirus infection on the NK cell receptor repertoire
M Gumá, A Angulo, C Vilches, N Gómez-Lozano… - Blood, 2004 - ashpublications.org
Expression of the activating CD94/NKG2C killer lectin-like receptor (KLR) specific for HLA-E
was analyzed in peripheral blood lymphocytes (PBLs) from healthy adult blood donors; the …
was analyzed in peripheral blood lymphocytes (PBLs) from healthy adult blood donors; the …
Self-tolerance of natural killer cells
Natural killer (NK) cells, similar to other lymphocytes, acquire tolerance to self. This means
that NK cells have the potential to attack normal self cells but that there are mechanisms to …
that NK cells have the potential to attack normal self cells but that there are mechanisms to …