Numerous studies have been carried out during the past 30 years on basic mechanisms
operative in carbon tetrachloride hepatotoxicity. These studies, which have been …

Liver cell injury induced by carbon tetrachloride involves initially the metabolism of carbon
tetrachloride to trichloromethyl free-radical by the mixed function oxidase system of the …

Three models of free radical-induced cell injury are presented in this review. Each model is
described by the mechanism of action of few prototype toxic molecules. Carbon tetrachloride …

An unknown chain of causality links the early events of CCl 4 metabolism to emergence of
the classical spectrum of pathological changes elicited by this hepatotoxin. Recent …

Many foreign compounds and endogenous substances are conjugated with glucuronic acid
to form water-soluble conjugates which are readily excreted in the urine or bile 11, 21 …

The major use of N-acetylcysteine in clinical toxicology is in the treatment of acetaminophen
(paracetamol) overdosage. The hepatorenal toxicity of acetaminophen is mediated by a …

The first edition of this book, Chemical Warfare Agents: Toxicity at Low Levels, was
published just prior to the terrorist attacks of September 11th, 2001. Reflecting a greater …

The chemical reaction of 1, 4-benzoquinone with glutathione results in the formation of
adducts that exhibit increasing degrees of glutathione substitution. Purification of these …

Organ toxicity is rare in patients exposed to inhaled anesthetics, but it is of particular clinical
concern because its occurrence is highly unpredictable and because it may result in severe …

Many potentially toxic electrophilic xenobiotics and some endogenous compounds are
detoxified by conversion to the corresponding glutathione S-conjugate, which is metabolized …