Human infection with Mycobacterium tuberculosis can progress to active disease, be
contained as latent infection, or be eradicated by the host response. Tuberculosis …

Neopterin is produced by activated monocytes, macrophages, and dendritic cells upon
stimulation by interferon gamma produced by T‐lymphocytes. Quantification of neopterin in …

In light of the marked global health impact of tuberculosis (TB), strong focus has been on
identifying biosignatures. Gene expression profiles in blood cells identified so far are …

More efficacious treatment regimens are needed for tuberculosis, however, drug
development is impeded by a lack of reliable biomarkers of disease severity and of …

New drugs, vaccines, and other therapies will be required to realise the goal of global
tuberculosis elimination or control. This Review covers the important role biomarkers can …

Neopterin is a pyrazino-pyrimidine compound that belongs to the pteridine group. It is known
to be a biochemical marker associated with cell-mediated immunity. It is produced by human …

The high incidence of tuberculosis (TB) infection is of great concern world-wide. The
traditional TB diagnostic techniques are not ideal for TB diagnosis in resource-poor …

Rationale Biomarkers for monitoring response to anti-tuberculosis treatment are needed. We
explored immune markers previously published as having predictive capability for 8 week …

Currently the ultimate success of anti-TB therapy is measured by the relapse rate within the
first 2years after treatment. The long duration of clinical trials that rely on this outcome …

Background Neopterin (NEO) is a marker of immune stimulation. Increased NEO levels have
been associated with autoimmune diseases, infections, and malignancies. Studies of NEO …