DNA topoisomerases: Advances in understanding of cellular roles and multi‐protein complexes via structure‐function analysis
DNA topoisomerases, capable of manipulating DNA topology, are ubiquitous and
indispensable for cellular survival due to the numerous roles they play during DNA …
indispensable for cellular survival due to the numerous roles they play during DNA …
All tangled up: how cells direct, manage and exploit topoisomerase function
SM Vos, EM Tretter, BH Schmidt… - Nature reviews Molecular …, 2011 - nature.com
Topoisomerases are complex molecular machines that modulate DNA topology to maintain
chromosome superstructure and integrity. Although capable of stand-alone activity in vitro …
chromosome superstructure and integrity. Although capable of stand-alone activity in vitro …
DNA topoisomerases: structure, function, and mechanism
JJ Champoux - Annual review of biochemistry, 2001 - annualreviews.org
▪ Abstract DNA topoisomerases solve the topological problems associated with DNA
replication, transcription, recombination, and chromatin remodeling by introducing …
replication, transcription, recombination, and chromatin remodeling by introducing …
Cellular roles of DNA topoisomerases: a molecular perspective
JC Wang - Nature reviews Molecular cell biology, 2002 - nature.com
DNA topoisomerases are the magicians of the DNA world—by allowing DNA strands or
double helices to pass through each other, they can solve all of the topological problems of …
double helices to pass through each other, they can solve all of the topological problems of …
Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with …
MJ Hendzel, Y Wei, MA Mancini, A Van Hooser… - Chromosoma, 1997 - Springer
We have generated and characterized a novel site-specific antibody highly specific for the
phosphorylated form of the amino-terminus of histone H3 (Ser10). In this study, we used this …
phosphorylated form of the amino-terminus of histone H3 (Ser10). In this study, we used this …
DNA topoisomerase II and its growing repertoire of biological functions
JL Nitiss - Nature Reviews Cancer, 2009 - nature.com
DNA topoisomerases are enzymes that disentangle the topological problems that arise in
double-stranded DNA. Many of these can be solved by the generation of either single or …
double-stranded DNA. Many of these can be solved by the generation of either single or …
Cell cycle-dependent control and roles of DNA topoisomerase II
JH Lee, JM Berger - Genes, 2019 - mdpi.com
Type II topoisomerases are ubiquitous enzymes in all branches of life that can alter DNA
superhelicity and unlink double-stranded DNA segments during processes such as …
superhelicity and unlink double-stranded DNA segments during processes such as …
ZIP1 is a synaptonemal complex protein required for meiotic chromosome synapsis
M Sym, JA Engebrecht, GS Roeder - Cell, 1993 - cell.com
Z/PI is a novel meiosis-specific gene required forchromosome synapsis and cell cycle
progression in S. cerevidae. z/p7 strains undergo homologous chromosome pairing, but are …
progression in S. cerevidae. z/p7 strains undergo homologous chromosome pairing, but are …
Condensins, chromosome condensation protein complexes containing XCAP-C, XCAP-E and a Xenopus homolog of the Drosophila Barren protein
T Hirano, R Kobayashi, M Hirano - Cell, 1997 - cell.com
We report here purification and characterization of chro-mosome condensation protein
complexes (termed condensins) containing XCAP-C and XCAP-E, two Xenopus members of …
complexes (termed condensins) containing XCAP-C and XCAP-E, two Xenopus members of …
Topoisomerase IIα in chromosome instability and personalized cancer therapy
Genome instability is a hallmark of cancer cells. Chromosome instability (CIN), which is often
mutually exclusive from hypermutation genotypes, represents a distinct subtype of genome …
mutually exclusive from hypermutation genotypes, represents a distinct subtype of genome …