Neuropathic pain: From actual pharmacological treatments to new therapeutic horizons

M Thouaye, I Yalcin - Pharmacology & Therapeutics, 2023 - Elsevier
Neuropathic pain, caused by a lesion or disease affecting the somatosensory system, affects
between 3 and 17% of the general population. The treatment of neuropathic pain is …

[HTML][HTML] Advances and challenges in neuropathic pain: a narrative review and future directions

N Attal, D Bouhassira, L Colvin - British Journal of Anaesthesia, 2023 - Elsevier
Over the past few decades, substantial advances have been made in neuropathic pain
clinical research. An updated definition and classification have been agreed. Validated …

Targeting the interplay of autophagy and ROS for cancer therapy: An updated overview on phytochemicals

L Dong, J He, L Luo, K Wang - Pharmaceuticals, 2023 - mdpi.com
Autophagy is an evolutionarily conserved self-degradation system that recycles cellular
components and damaged organelles, which is critical for the maintenance of cellular …

Multiple modulatory roles of serotonin in chronic pain and injury-related anxiety

S Hao, W Shi, W Liu, QY Chen, M Zhuo - Frontiers in Synaptic …, 2023 - frontiersin.org
Chronic pain is long-lasting pain that often persists during chronic diseases or after recovery
from disease or injury. It often causes serious side effects, such as insomnia, anxiety, or …

Biphasic dose response in the anti-inflammation experiment of PBM

F Nie, S Hao, Y Ji, Y Zhang, H Sun, M Will… - Lasers in medical …, 2023 - Springer
Non-invasive laser irradiation can induce photobiomodulation (PBM) effects in cells and
tissues, which can help reduce inflammation and pain in several clinical scenarios. The …

The Utility of Capsicum annuum L. in Internal Medicine and In Dentistry: A Comprehensive Review

LM Catalfamo, G Marrone, M Basilicata… - International Journal of …, 2022 - mdpi.com
Capsaicin is a chili peppers extract, genus Capsicum, commonly used as a food spice.
Since ancient times, Capsaicin has been used as a “homeopathic remedy” for treating a wild …

Role of resolvins in inflammatory and neuropathic pain

J Park, J Roh, J Pan, YH Kim, CK Park, YY Jo - Pharmaceuticals, 2023 - mdpi.com
Chronic pain is an unpleasant experience associated with actual or potential tissue damage.
Inflammatory pain alerts the body to inflammation and promotes healing; however …

Capsaicin orchestrates metastasis in gastric cancer via modulating expression of TRPV1 channels and driving gut microbiota disorder

R Deng, S Yu, X Ruan, H Liu, G Zong, P Cheng… - Cell Communication and …, 2023 - Springer
The association between capsaicin, the major natural pungent compound of chili peppers,
and gastric cancer progression has engendered conflicting findings. In this work, we sought …

Role of transforming growth factor-β in peripheral nerve regeneration

Z Ding, M Jiang, J Qian, D Gu, H Bai… - Neural Regeneration …, 2023 - journals.lww.com
Injuries caused by trauma and neurodegenerative diseases can damage the peripheral
nervous system and cause functional deficits. Unlike in the central nervous system …

TRPV1 in chronic pruritus and pain: Soft modulation as a therapeutic strategy

A Fernández-Carvajal… - Frontiers in Molecular …, 2022 - frontiersin.org
Chronic pain and pruritus are highly disabling pathologies that still lack appropriate
therapeutic intervention. At cellular level the transduction and transmission of pain and …