The majority of potentially preventable deaths after trauma are related to hemorrhage and
occur early after injury, with the largest number of deaths occurring before hospital arrival …

Trauma remains a leading cause of death worldwide, and most early preventable deaths in
both the civilian and military settings are due to uncontrolled hemorrhage, despite paradigm …

Importance In-hospital administration of tranexamic acid after injury improves outcomes in
patients at risk for hemorrhage. Data demonstrating the benefit and safety of the pragmatic …

Importance Severely injured patients experiencing hemorrhagic shock often require massive
transfusion. Earlier transfusion with higher blood product ratios (plasma, platelets, and red …

Background: Massive transfusion protocols (MTPs) have become standard of care in the
management of bleeding injured patients, yet strategies to guide them vary widely. We …

Death happening due to massive hemorrhage has been involved in military conflicts, traffic
accidents, and surgical injuries of various human disasters. Achieving rapid and effective …

Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …

Importance The need for improved methods of hemorrhage control and resuscitation has
resulted in a reappraisal of resuscitative endovascular balloon occlusion of the aorta …

Background Over the last decade the age of trauma patients and injury mortality has
increased. At the same time, many centers have implemented multiple interventions focused …

Rationale The implementation of mass spectrometry (MS)based metabolomics is
advancing many areas of biomedical research. The time associated with traditional …