Outcomes of traumatic hemorrhagic shock and the epidemiology of preventable death from injury
BJ Eastridge, JB Holcomb, S Shackelford - Transfusion, 2019 - Wiley Online Library
The majority of potentially preventable deaths after trauma are related to hemorrhage and
occur early after injury, with the largest number of deaths occurring before hospital arrival …
occur early after injury, with the largest number of deaths occurring before hospital arrival …
[HTML][HTML] Trauma‐induced coagulopathy: the past, present, and future
LZ Kornblith, HB Moore, MJ Cohen - Journal of thrombosis and …, 2019 - Elsevier
Trauma remains a leading cause of death worldwide, and most early preventable deaths in
both the civilian and military settings are due to uncontrolled hemorrhage, despite paradigm …
both the civilian and military settings are due to uncontrolled hemorrhage, despite paradigm …
Tranexamic acid during prehospital transport in patients at risk for hemorrhage after injury: a double-blind, placebo-controlled, randomized clinical trial
FX Guyette, JB Brown, MS Zenati, BJ Early-Young… - JAMA …, 2021 - jamanetwork.com
Importance In-hospital administration of tranexamic acid after injury improves outcomes in
patients at risk for hemorrhage. Data demonstrating the benefit and safety of the pragmatic …
patients at risk for hemorrhage. Data demonstrating the benefit and safety of the pragmatic …
Transfusion of plasma, platelets, and red blood cells in a 1: 1: 1 vs a 1: 1: 2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial
JB Holcomb, BC Tilley, S Baraniuk, EE Fox, CE Wade… - Jama, 2015 - jamanetwork.com
Importance Severely injured patients experiencing hemorrhagic shock often require massive
transfusion. Earlier transfusion with higher blood product ratios (plasma, platelets, and red …
transfusion. Earlier transfusion with higher blood product ratios (plasma, platelets, and red …
Goal-directed hemostatic resuscitation of trauma-induced coagulopathy: a pragmatic randomized clinical trial comparing a viscoelastic assay to conventional …
Background: Massive transfusion protocols (MTPs) have become standard of care in the
management of bleeding injured patients, yet strategies to guide them vary widely. We …
management of bleeding injured patients, yet strategies to guide them vary widely. We …
A super tough, rapidly biodegradable, ultrafast hemostatic bioglue
H Wang, J Cheng, F Sun, X Dou, J Liu… - Advanced …, 2023 - Wiley Online Library
Death happening due to massive hemorrhage has been involved in military conflicts, traffic
accidents, and surgical injuries of various human disasters. Achieving rapid and effective …
accidents, and surgical injuries of various human disasters. Achieving rapid and effective …
Trauma-induced coagulopathy
Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …
Nationwide analysis of resuscitative endovascular balloon occlusion of the aorta in civilian trauma
Importance The need for improved methods of hemorrhage control and resuscitation has
resulted in a reappraisal of resuscitative endovascular balloon occlusion of the aorta …
resulted in a reappraisal of resuscitative endovascular balloon occlusion of the aorta …
Trends in 1029 trauma deaths at a level 1 trauma center: impact of a bleeding control bundle of care
BT Oyeniyi, EE Fox, M Scerbo, JS Tomasek, CE Wade… - Injury, 2017 - Elsevier
Background Over the last decade the age of trauma patients and injury mortality has
increased. At the same time, many centers have implemented multiple interventions focused …
increased. At the same time, many centers have implemented multiple interventions focused …
A three‐minute method for high‐throughput quantitative metabolomics and quantitative tracing experiments of central carbon and nitrogen pathways
Rationale The implementation of mass spectrometry (MS)‐based metabolomics is
advancing many areas of biomedical research. The time associated with traditional …
advancing many areas of biomedical research. The time associated with traditional …