In recent years, many members of the FK506-binding protein (FKBP) family were
increasingly linked to various diseases. The binding domain of FKBPs differs only in a few …

Calcium homeostasis plays an essential role in maintaining excitation–contraction coupling
(ECC) in cardiomyocytes, including calcium release, recapture, and storage. Disruption of …

Abstract FK506 (Tacrolimus), isolated from Streptomyces tsukubaenis is a powerful
immunosuppressant shown to inhibit T cell activation. FK506 mediated immunosuppression …

Abstract Loss-of-function (LOF) variants in SCN1B, encoding voltage-gated sodium channel
β1 subunits, are linked to human diseases with high risk of sudden death, including …

Simultaneous dysregulation of multiple microRNAs (miRs) affects various pathological
pathways related to cardiac failure. In addition to being potential cardiac disease-specific …

Studies suggest the potential role of a sarcoplasmic reticulum (SR) Ca 2+ leak in cardiac
contractile dysfunction in sepsis. However, direct supporting evidence is lacking, and the …

Mitochondrial protein sequence similarity 3 gene family member A (FAM3A) plays important
roles in the electron transfer chain, while its functions in the heart are still unknown. This …

Abstract Aims The ryanodine receptor 2 (RyR2) is essential for cardiac muscle excitation–
contraction coupling; dysfunctional RyR2 participates in the development of inherited …

Myocardial calcium (Ca 2+) signaling plays a crucial role in contractile function and
membrane electrophysiology. An abnormal myocardial Ca 2+ transient is linked to heart …

Background Post-defibrillation myocardial contractile dysfunction adversely affects the
survival of patients after cardiac arrest. Attenuation of diastolic calcium (Ca 2+) overload by …