Cyclodextrins (CDs) have been widely investigated as a unique pharmaceutical excipient for
past few decades and is still explored for new applications. They are highly versatile …

Cyclodextrins are cyclic oligosaccharides obtained by enzymatic digestion of starch. The α-,
β-and γ-cyclodextrins contain respectively 6, 7 and 8 glucopyranose units, with primary and …

The development of effective drug delivery systems is very challenging due to poor
solubility, low membrane permeability, instability, and short biological half-life of active …

Background: Cyclodextrins (CDs) are versatile excipients with an essential role in drug
delivery, as they can form non-covalently bonded inclusion complexes (host-guest …

Chemotherapeutic drugs for colorectal cancer (CRC) which is currently the third most lethal
cancer globally, are administered intravenously (iv) due to their low oral bioavailability …

Cancer is one of the major fatal diseases. Chemotherapy is a typical treatment method that
uses a combination of drugs to either destroy cancer cells or slow down the growth of cancer …

Idebenone (IDE), a synthetic short-chain analogue of coenzyme Q10, is a potent antioxidant
able to prevent lipid peroxidation and stimulate nerve growth factor. Due to these properties …

Cyclodextrin molecules are cyclic oligosaccharides that display a unique structure including
an inner side and two faces on their outer sides. Each face and the inner core can be …

Background This was a phase I/IIa study to investigate the tolerability, efficacy and
pharmacokinetics (PK)/pharmacodynamics (PD) of CRLX301, CDP-based nanoparticle …

Background: Paclitaxel is a potent anticancer drug that is effective against a wide spectrum
of cancers. To overcome its bioavailability problems arising from very poor aqueous …