The toxicity of nanoparticles and their interaction with cells: an in vitro metabolomic perspective
Nowadays, nanomaterials (NMs) are widely present in daily life due to their significant
benefits, as demonstrated by their application in many fields such as biomedicine …
benefits, as demonstrated by their application in many fields such as biomedicine …
Omics approaches for the assessment of biological responses to nanoparticles
Y Abdelkader, L Perez-Davalos, R LeDuc… - Advanced Drug Delivery …, 2023 - Elsevier
Nanotechnology has enabled the development of innovative therapeutics, diagnostics, and
drug delivery systems. Nanoparticles (NPs) can influence gene expression, protein …
drug delivery systems. Nanoparticles (NPs) can influence gene expression, protein …
Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects
Mammalian cells generate citrate by decarboxylating pyruvate in the mitochondria to supply
the tricarboxylic acid (TCA) cycle. In contrast, hypoxia and other impairments of …
the tricarboxylic acid (TCA) cycle. In contrast, hypoxia and other impairments of …
Hypoxia-mediated increases in L-2-hydroxyglutarate coordinate the metabolic response to reductive stress
Metabolic adaptation to hypoxia is critical for survival in metazoan species for which reason
they have developed cellular mechanisms for mitigating its adverse consequences. Here …
they have developed cellular mechanisms for mitigating its adverse consequences. Here …
Clinical metabolomics: the new metabolic window for inborn errors of metabolism investigations in the post-genomic era
Inborn errors of metabolism (IEM) represent a group of about 500 rare genetic diseases with
an overall estimated incidence of 1/2500. The diversity of metabolic pathways involved …
an overall estimated incidence of 1/2500. The diversity of metabolic pathways involved …
Genetic basis of mitochondrial diseases
M Gusic, H Prokisch - FEBS letters, 2021 - Wiley Online Library
Mitochondrial disorders are monogenic disorders characterized by a defect in oxidative
phosphorylation and caused by pathogenic variants in one of over 340 different genes. The …
phosphorylation and caused by pathogenic variants in one of over 340 different genes. The …
Metabolomics of mitochondrial disease
K Esterhuizen, FH Van der Westhuizen, R Louw - Mitochondrion, 2017 - Elsevier
Mitochondrial disease (MD) diagnostics and disease progression investigations have
traditionally relied very little on metabolic data, due to a lack of biomarker sensitivity and …
traditionally relied very little on metabolic data, due to a lack of biomarker sensitivity and …
Quantitative metabolic flux analysis reveals an unconventional pathway of fatty acid synthesis in cancer cells deficient for the mitochondrial citrate transport protein
The mitochondrial citrate transport protein (CTP), encoded by SLC25A1, accommodates
bidirectional trafficking of citrate between the mitochondria and cytosol, supporting lipid …
bidirectional trafficking of citrate between the mitochondria and cytosol, supporting lipid …
DNA methylation associated with mitochondrial dysfunction in a South African autism spectrum disorder cohort
S Stathopoulos, R Gaujoux, Z Lindeque… - Autism …, 2020 - Wiley Online Library
Autism spectrum disorder (ASD) is characterized by phenotypic heterogeneity and a
complex genetic architecture which includes distinctive epigenetic patterns. We report …
complex genetic architecture which includes distinctive epigenetic patterns. We report …
[HTML][HTML] Mitochondrial stress causes neuronal dysfunction via an ATF4-dependent increase in L-2-hydroxyglutarate
RJ Hunt, L Granat, GS McElroy, R Ranganathan… - Journal of Cell …, 2019 - rupress.org
Mitochondrial stress contributes to a range of neurological diseases. Mitonuclear signaling
pathways triggered by mitochondrial stress remodel cellular physiology and metabolism …
pathways triggered by mitochondrial stress remodel cellular physiology and metabolism …