Ewing sarcoma, a highly aggressive bone and soft-tissue cancer, is considered a prime
example of the paradigms of a translocation-positive sarcoma: a genetically rather simple …

Over nearly 70 years, polymers have revolutionized the global economy, manufacturing and,
mainly, the fields which require biocompatible materials, as food technology and packaging …

The advent of iPSCs has brought about a significant transformation in stem cell research,
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …

Highlights•Characteristics of the tumor microenvironment that have to be considered for the
development of 3D cell spheroid model systems for translational cancer research.•Methods …

The fate of tumors depends both on the cancer cells' intrinsic characteristics and on the
environmental conditions where the tumors reside and grow. Engineered in vitro models …

This may be the most exciting time ever for the field of tissue engineering and regenerative
medicine (TERM). After decades of progress, it has matured, integrated, and diversified into …

Cancer treatment is rapidly evolving toward personalized medicine, which takes into
account the individual molecular and genetic variability of tumors. Sophisticated new in vitro …

Three-dimensional tumor models accurately describe different aspects of the tumor
microenvironment and are readily available for mechanistic studies of tumor biology and for …

Bone primary tumors, such as osteosarcoma, are highly aggressive pediatric tumors that in
30% of the cases develop lung metastasis and are characterized by poor prognosis. Bone is …

Anticancer compound screening on 2D cell cultures poorly predicts “in vivo” performance,
while conventional 3D culture systems are usually characterized by limited cell proliferation …