Metal neurotoxicity is a global health concern. This paper summarizes the evidence for
metal interactions with synaptic transmission and synaptic plasticity. Presynaptically metal …

Environmental toxicants are thought to play a major role in the pathogenesis of Parkinson's
disease. In reviewing the literature on heavy metals known to be toxicants, we noted several …

Seabirds often have high loads of contaminants. These contaminants have endocrine
disrupting properties but their relationships with some endocrine mechanisms are still poorly …

Consumption of contaminated Great Lakes fish by pregnant women is associated with
decreased birth weight and deficits in cognitive function in their infants and children. These …

The costs associated with a drug's clinical trials are so significant that it has become
necessary to validate both its safety and efficacy in animal models prior to the continued …

Mercury (Hg) exposure remains a major public health concern due to its widespread
distribution in the environment. Organic mercurials, such as MeHg, have been extensively …

Methylmercury (MeHg) produces significant increases in the spontaneous output of
dopamine (DA) from rat striatal tissue. The mechanism through MeHg produces such …

Polychlorinated biphenyls (PCBs) and methylmercury (MeHg) are ubiquitous environmental
contaminants that alter cognitive function in both humans and animals. Because PCBs and …

Methylmercury (MeHg) is an environmental neurotoxicant that is especially harmful during
brain development. Previously, we found greater sensitivity to MeHg-induced oxidative …

Monoamine oxidase (MAO) regulates levels of dopamine, serotonin, and noradrenaline in
the nervous tissue and is required for proper neuronal development. The purpose of this …