The role of ABC transporters in ovarian cancer progression and chemoresistance
Over 80% of ovarian cancer patients develop chemoresistance which results in a lethal
course of the disease. A well-established cause of chemoresistance involves the family of …
course of the disease. A well-established cause of chemoresistance involves the family of …
Tyrosine kinase inhibitors enhanced the efficacy of conventional chemotherapeutic agent in multidrug resistant cancer cells
S Wu, L Fu - Molecular cancer, 2018 - Springer
Multidrug resistance (MDR) triggered by ATP binding cassette (ABC) transporter such as
ABCB1, ABCC1, ABCG2 limited successful cancer chemotherapy. Unfortunately, no …
ABCB1, ABCC1, ABCG2 limited successful cancer chemotherapy. Unfortunately, no …
Tetrandrine and fangchinoline, bisbenzylisoquinoline alkaloids from Stephania tetrandra can reverse multidrug resistance by inhibiting P-glycoprotein activity in …
YF Sun, M Wink - Phytomedicine, 2014 - Elsevier
The overexpression of ABC transporters is a common reason for multidrug resistance (MDR)
in cancer cells. In this study, we found that the isoquinoline alkaloids tetrandrine and …
in cancer cells. In this study, we found that the isoquinoline alkaloids tetrandrine and …
Repurposing tyrosine kinase inhibitors to overcome multidrug resistance in cancer: a focus on transporters and lysosomal sequestration
M Krchniakova, J Skoda, J Neradil, P Chlapek… - International journal of …, 2020 - mdpi.com
Tyrosine kinase inhibitors (TKIs) are being increasingly used to treat various malignancies.
Although they were designed to target aberrant tyrosine kinases, they are also intimately …
Although they were designed to target aberrant tyrosine kinases, they are also intimately …
Nobiletin enhances the efficacy of chemotherapeutic agents in ABCB1 overexpression cancer cells
W Ma, S Feng, X Yao, Z Yuan, L Liu, Y Xie - Scientific reports, 2015 - nature.com
Multidrug resistance (MDR) is the major obstacle to the successful chemotherapy treatment
of many cancers. Here we found that nobiletin, a citrus methoxyflavone, significantly …
of many cancers. Here we found that nobiletin, a citrus methoxyflavone, significantly …
Role of the Fyn-PKCδ signaling in SE-induced neuroinflammation and epileptogenesis in experimental models of temporal lobe epilepsy
Status epilepticus (SE) induces neuroinflammation and epileptogenesis, but the
mechanisms are not yet fully delineated. The Fyn, a non-receptor Src family tyrosine kinase …
mechanisms are not yet fully delineated. The Fyn, a non-receptor Src family tyrosine kinase …
ABC transporter inhibitors in reversing multidrug resistance to chemotherapy
H Cui, AJ Zhang, M Chen, JJ Liu - Current drug targets, 2015 - ingentaconnect.com
The superfamily of human ATP-binding cassette (ABC) transporters comprises seven
subfamilies (ABCA to G) with 48 members. In addition to their profound physiological and …
subfamilies (ABCA to G) with 48 members. In addition to their profound physiological and …
Fyn tyrosine kinase, a downstream target of receptor tyrosine kinases, modulates antiglioma immune responses
Background High-grade gliomas are aggressive and immunosuppressive brain tumors.
Molecular mechanisms that regulate the inhibitory immune tumor microenvironment (TME) …
Molecular mechanisms that regulate the inhibitory immune tumor microenvironment (TME) …
[HTML][HTML] Reversal of P-gp-mediated multidrug resistance in colon cancer by cinobufagin
Z Yuan, X Shi, Y Qiu, T Jia, X Yuan… - Oncology …, 2017 - spandidos-publications.com
Cinobufagin (CBF) is isolated from the skin and posterior auricular glands of the Asiatic toad
(Bufo gargarizans). This study investigated the reversal effect of CBF on P-glycoprotein (P …
(Bufo gargarizans). This study investigated the reversal effect of CBF on P-glycoprotein (P …
Mechanisms of disease-modifying effect of saracatinib (AZD0530), a Src/Fyn tyrosine kinase inhibitor, in the rat kainate model of temporal lobe epilepsy
S Sharma, S Carlson, A Gregory-Flores… - Neurobiology of …, 2021 - Elsevier
We have recently demonstrated the role of the Fyn-PKCδ signaling pathway in status
epilepticus (SE)-induced neuroinflammation and epileptogenesis in experimental models of …
epilepticus (SE)-induced neuroinflammation and epileptogenesis in experimental models of …