In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …

The extracellular matrix (ECM) is a highly dynamic structure that is present in all tissues and
continuously undergoes controlled remodelling. This process involves quantitative and …

Circular RNAs (circRNAs) represent a class of non-coding RNAs that are widely expressed
in mammals. However, it is largely unknown about the function of human circRNAs and the …

Cancer has become the second greatest cause of death worldwide. Although there are
several different classes of anticancer drugs that are available in clinic, some tough issues …

Acute myocardial infarction (MI) due to coronary artery occlusion is accompanied by a
pathological remodeling response that includes hypertrophic cardiac growth and fibrosis …

Synthesis and deposition of extracellular matrix (ECM) within the glomerulus and interstitium
characterizes renal fibrosis, but the mechanisms underlying this process are incompletely …

The human miR-29 family of microRNAs has three mature members, miR-29a, miR-29b, and
miR-29c. miR-29s are encoded by two gene clusters. Binding sites for several transcriptional …

Integrated genomic analyses revealed a miRNA-regulatory network that further defined a
robust integrated mesenchymal subtype associated with poor overall survival in 459 cases …

Objective To investigate the role of microRNA (miRNA) as posttranscriptional regulators of
profibrotic genes in systemic sclerosis (SSc). Methods MicroRNA, which target collagens …

Recently, microRNAs (miRNAs) have been discovered to have a role in metastasis. Here we
describe how miRNAs are involved in advanced stages of tumour progression, stressing …