Optimisation of pharmacotherapy in psychiatry through therapeutic drug monitoring, molecular brain imaging and pharmacogenetic tests: Focus on antipsychotics

XM Hart, G Gründer, N Ansermot, A Conca… - The World Journal of …, 2024 - Taylor & Francis
Background For psychotic disorders (ie schizophrenia), pharmacotherapy plays a key role in
controlling acute and long-term symptoms. To find the optimal individual dose and dosage …

[HTML][HTML] Influence of CYP2C19 and CYP2D6 on side effects of aripiprazole and risperidone: A systematic review

E de Brabander, KK Schaars, T van Amelsvoort… - Journal of Psychiatric …, 2024 - Elsevier
Variability in hepatic cytochrome P450 (CYP) enzymes such as 2C19 and 2D6 may
influence side-effect and efficacy outcomes for antipsychotics. Aripiprazole and risperidone …

influence of the CYP450 genetic variation on the treatment of psychotic disorders

L Carrascal-Laso, M Isidoro-García… - Journal of Clinical …, 2021 - mdpi.com
Second-generation antipsychotic metabolism is mainly carried out by the CYP450
superfamily, which is highly polymorphic. Therefore, knowing the influence of the different …

Metabolic effects of aripiprazole and olanzapine multiple-dose treatment in a randomised crossover clinical trial in healthy volunteers: association with …

D Koller, S Almenara, G Mejía, M Saiz-Rodríguez… - Advances in …, 2021 - Springer
Introduction Aripiprazole and olanzapine are atypical antipsychotics. Both drugs can induce
metabolic changes; however, the metabolic side effects produced by aripiprazole are more …

Chronic Aripiprazole and Trazodone Polypharmacy Effects on Systemic and Brain Cholesterol Biosynthesis

Z Korade, A Anderson, M Balog, KA Tallman, NA Porter… - Biomolecules, 2023 - mdpi.com
The concurrent use of several medications is a common practice in the treatment of complex
psychiatric conditions. One such commonly used combination is aripiprazole (ARI), an …

Pharmacogenomics and non-genetic factors affecting drug response in autism spectrum disorder in Thai and other populations: current evidence and future …

M Biswas, N Vanwong, C Sukasem - Frontiers in Pharmacology, 2024 - frontiersin.org
Autism spectrum disorder (ASD) may affect family and social life profoundly. Although there
is no selective pharmacotherapy for ASD, the Food and Drug Administration (FDA) has …

Pharmacogenomics factors influencing the effect of risperidone on prolactin levels in Thai pediatric patients with autism spectrum disorder

Y Hongkaew, A Gaedigk, B Wilffert… - Frontiers in …, 2021 - frontiersin.org
We investigated the association between genetic variations in pharmacodynamic genes and
risperidone-induced increased prolactin levels in children and adolescents with autism …

[HTML][HTML] Aripiprazole therapy and CYP2D6 genotype

L Dean, M Kane - 2021 - europepmc.org
Background Poor metabolizer Administer no more than 10 mg/day or 300 mg/month (67–
75% of the standard maximum dose of aripiprazole) 1 The risk of side effects is increased …

The pharmacogenetics of aripiprazole-induced hyperprolactinemia: what do we know?

D Koller, F Abad-Santos - Pharmacogenomics, 2020 - Taylor & Francis
Aripiprazole is an atypical antipsychotic used for the treatment of schizophrenia and bipolar
disorder. It is a secondgeneration (atypical) antipsychotic, frequently referred to as third …

Overview of prolactin levels in patients with schizophrenia during antipsychotic therapy at HB. Saanin Mental Hospital Padang, Indonesia

DH Dita Hasni, ESB Bayu Eka Surya… - Bali Medical …, 2023 - repository.unbrah.ac.id
Background: Schizophrenia, which affects about 0.85% of people worldwide, is the most
common illness among psychotic disorders. Antipsychotic drugs have been a mainstay of …