The rapid emergence of antifungal-resistant human-pathogenic fungi

SR Lockhart, A Chowdhary, JAW Gold - Nature Reviews Microbiology, 2023 - nature.com
During recent decades, the emergence of pathogenic fungi has posed an increasing public
health threat, particularly given the limited number of antifungal drugs available to treat …

Candida albicans biofilms and polymicrobial interactions

NO Ponde, L Lortal, G Ramage, JR Naglik… - Critical reviews in …, 2021 - Taylor & Francis
Candida albicans is a common fungus of the human microbiota. While generally a harmless
commensal in healthy individuals, several factors can lead to its overgrowth and cause a …

Antifungal tolerance is a subpopulation effect distinct from resistance and is associated with persistent candidemia

A Rosenberg, IV Ene, M Bibi, S Zakin, ES Segal… - Nature …, 2018 - nature.com
Tolerance to antifungal drug concentrations above the minimal inhibitory concentration
(MIC) is rarely quantified, and current clinical recommendations suggest it should be …

tRNA deregulation and its consequences in cancer

M Santos, A Fidalgo, AS Varanda, C Oliveira… - Trends in Molecular …, 2019 - cell.com
The expression of transfer RNAs (tRNAs) is deregulated in cancer cells but the mechanisms
and functional meaning of such deregulation are poorly understood. The proteome of cancer …

Evolutionary instability of CUG-Leu in the genetic code of budding yeasts

T Krassowski, AY Coughlan, XX Shen, X Zhou… - Nature …, 2018 - nature.com
The genetic code used in nuclear genes is almost universal, but here we report that it
changed three times in parallel during the evolution of budding yeasts. All three changes …

Global analysis of mutations driving microevolution of a heterozygous diploid fungal pathogen

IV Ene, RA Farrer, MP Hirakawa… - Proceedings of the …, 2018 - National Acad Sciences
Candida albicans is a heterozygous diploid yeast that is a commensal of the human
gastrointestinal tract and a prevalent opportunistic pathogen. Here, whole-genome …

SUMO and cellular adaptive mechanisms

HY Ryu, SH Ahn, M Hochstrasser - Experimental & Molecular Medicine, 2020 - nature.com
The ubiquitin family member SUMO is a covalent regulator of proteins that functions in
response to various stresses, and defects in SUMO-protein conjugation or deconjugation …

An overview on conventional and non-conventional therapeutic approaches for the treatment of candidiasis and underlying resistance mechanisms in clinical strains

SB Salazar, RS Simões, NA Pedro, MJ Pinheiro… - Journal of Fungi, 2020 - mdpi.com
Fungal infections and, in particular, those caused by species of the Candida genus, are
growing at an alarming rate and have high associated rates of mortality and morbidity …

Discovery of New Broad-Spectrum Anti-Infectives for Eukaryotic Pathogens Using Bioorganometallic Chemistry

Y Lin, H Jung, CA Bulman, J Ng, R Vinck… - Journal of Medicinal …, 2023 - ACS Publications
Drug resistance observed with many anti-infectives clearly highlights the need for new broad-
spectrum agents to treat especially neglected tropical diseases (NTDs) caused by eukaryotic …

Myrtle Seeds (Myrtus communis L.) as a Rich Source of the Bioactive Ellagitannins Oenothein B and Eugeniflorin D2

AM Franco, N Tocci, G Guella, M Dell'Agli… - ACS …, 2019 - ACS Publications
The increasing popularity of “Mirto” liqueur, produced from Myrtus communis berries, has led
to the planting of domesticated cultivars, expanding myrtle berry production. To promote the …