Host cell exit is a critical step in the life-cycle of intracellular pathogens, intimately linked to
barrier penetration, tissue dissemination, inflammation, and pathogen transmission. Like cell …

Toxoplasma gondii has a complex life cycle involving different hosts and is dependent on
fast responses, as the parasite reacts to changing environmental conditions. T. gondii …

Regulated microneme secretion governs motility, host cell invasion and egress in the
obligate intracellular apicomplexans. Intracellular calcium oscillations and phospholipid …

Toxoplasma gondii is a prevalent zoonotic pathogen infecting livestock as well as humans.
The exceptional ability of this parasite to reproduce in several types of nucleated host cells …

Lipid flipping in the membrane bilayers is a widespread eukaryotic phenomenon that is
catalyzed by assorted P4-ATPases. Its occurrence, mechanism, and importance in …

Toxoplasma gondii is an obligate intracellular parasite capable of infecting humans and
animals. The organism has extraordinary metabolic resilience that allows it to establish …

Successful inter-host transmission of most apicomplexan parasites requires the formation of
infective sporozoites within the oocysts. Unlike all other infective stages that are strictly …

Phosphatidylinositol (PtdIns) serves as an integral component of eukaryotic membranes;
however, its biosynthesis in apicomplexan parasites remains poorly understood. Here we …

The membrane asymmetry regulated by P4-ATPases is crucial for the functioning of
eukaryotic cells. The underlying spatial translocation or flipping of specific lipids is usually …

Glycerophospholipids have emerged as a significant contributor to the intracellular growth of
pathogenic protist Toxoplasma gondii. Phosphatidylserine (PtdSer) is one such lipid …