Hepadnaviruses (hepatitis B viruses) cause transient and chronic infections of the liver.
Transient infections run a course of several months, and chronic infections are often lifelong …

Approximately 5% of the world population is infected by the hepatitis B virus (HBV) that
causes a necroinflammatory liver disease of variable duration and severity. Chronically …

BACKGROUND & AIMS: The molecular biology of hepatitis B virus (HBV) has been
extensively studied but the exact role of the hepatitis BX protein (HBx) in the context of …

HBV cccDNA, the template for transcription of all viral mRNAs, accumulates in the nucleus of
infected cells as a stable episome organized into minichromosomes by histones and non …

Background & Aims: HBV covalently closed circular DNA (cccDNA), the replicative
intermediate responsible for persistent HBV infection of hepatocytes, is the template for …

With an estimate of 350 million people chronically infected with the hepatitis B virus (HBV)
worldwide, it is critically important to understand how persistent HBV infection is maintained …

Autophagy is a catabolic process by which cells remove long-lived proteins and damaged
organelles for recycling. Viral infections may also induce autophagic response. Here we …

The hepatitis B virus (HBV) counts as a major global health problem, as it presents a
significant causative factor for liver-related morbidity and mortality. The development of …

The X gene of the mammalian hepadnaviruses is believed to encode a protein of 17 kDa
which has been shown to transactivate a wide range of viral and cellular promoters. The …

Chronic infection of hepatitis B virus (HBV) is one of the major causes of hepatocellular
carcinoma (HCC) in the world. Hepatitis B virus X protein (HBx) has been long suspected to …