The accumulation of amyloid-β protein (Aβ) plays an early role in the pathogenesis of
Alzheimer's disease (AD). The precise mechanism of how Aβ accumulation leads to synaptic …

Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors that are
activated by glutamate in the central nervous system (CNS). Basically, mGluRs contribute to …

Metabotropic glutamate (mGlu) receptor protomers can heterodimerize, leading to different
pharmacology compared to their homodimeric counterparts. Here, we use complemented …

BACE1 initiates production of β-amyloid peptides (Aβ), which is associated with cognitive
dysfunction in Alzheimer's disease (AD) due to abnormal oligomerization and aggregation …

Autism spectrum disorder (ASD) and Alzheimer's disease (AD) are neurodevelopmental and
neurodegenerative disorders affecting two opposite ends of life span, ie, childhood and old …

Background Metabotropic glutamate receptor 5 (mGluR5) is involved in regulating
integrative brain function and synaptic transmission. Aberrant mGluR5 signaling and …

Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) stand as the prevailing
sources of neurodegenerative dementia, impacting over 55 million individuals across the …

Excessive activation of N-methyl-d-aspartic acid (NMDA) receptors after cerebral ischemia is
a key cause of ischemic injury. For a long time, it was generally accepted that calcium influx …

Alzheimer's disease (AD) is marked by chronic neurodegeneration associated with the
occurrence of plaques containing amyloid β (Aβ) proteins in various parts of the human …

Heavy drinking can induce early-onset dementia and increase the likelihood of the
progression and severity of Alzheimer's Disease and related dementias (ADRD). Recently …