Sustained release glaucoma therapies: Novel modalities for overcoming key treatment barriers associated with topical medications
Glaucoma is a progressive optic neuropathy and a leading cause of irreversible blindness.
The disease has conventionally been characterized by an elevated intraocular pressure …
The disease has conventionally been characterized by an elevated intraocular pressure …
Matrix metalloproteinases and glaucoma treatment
RN Weinreb, MR Robinson, M Dibas… - Journal of Ocular …, 2020 - liebertpub.com
Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that degrade
extracellular matrix (ECM) components such as collagen and have important roles in …
extracellular matrix (ECM) components such as collagen and have important roles in …
[HTML][HTML] Performance and safety of a new ab interno gelatin stent in refractory glaucoma at 12 months
DS Grover, WJ Flynn, KP Bashford, RA Lewis… - American journal of …, 2017 - Elsevier
Purpose To evaluate the intraocular pressure (IOP)-lowering performance and safety of an
ab interno gelatin stent (XEN 45 Gel Stent, Allergan plc, Irvine, California, USA), a minimally …
ab interno gelatin stent (XEN 45 Gel Stent, Allergan plc, Irvine, California, USA), a minimally …
A prospective randomized trial comparing Hydrus and iStent microinvasive glaucoma surgery implants for standalone treatment of open-angle glaucoma: the …
Purpose To compare the efficacy of different microinvasive glaucoma surgery (MIGS)
devices for reducing intraocular pressure (IOP) and medications in open-angle glaucoma …
devices for reducing intraocular pressure (IOP) and medications in open-angle glaucoma …
The most common barriers to glaucoma medication adherence: a cross-sectional survey
Purpose To evaluate the frequency of 11 commonly cited barriers to optimal glaucoma
medication adherence among glaucoma patients and to identify barriers contributing to poor …
medication adherence among glaucoma patients and to identify barriers contributing to poor …
[HTML][HTML] Phase 3, randomized, 20-month study of bimatoprost implant in open-angle glaucoma and ocular hypertension (ARTEMIS 1)
FA Medeiros, TR Walters, M Kolko, M Coote… - Ophthalmology, 2020 - Elsevier
Purpose To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of 10-and
15-μg bimatoprost implant in subjects with open-angle glaucoma (OAG) and ocular …
15-μg bimatoprost implant in subjects with open-angle glaucoma (OAG) and ocular …
Three-year findings of the HORIZON trial: a Schlemm canal microstent for pressure reduction in primary open-angle glaucoma and cataract
IIK Ahmed, DJ Rhee, J Jones, IP Singh, N Radcliffe… - Ophthalmology, 2021 - Elsevier
Purpose To report 3-year outcomes of the HORIZON study comparing cataract surgery (CS)
with Hydrus Microstent (Ivantis, Inc) implantation versus CS alone. Design Multicenter …
with Hydrus Microstent (Ivantis, Inc) implantation versus CS alone. Design Multicenter …
A drug-eluting contact lens
JB Ciolino, TR Hoare, NG Iwata… - … & visual science, 2009 - iovs.arvojournals.org
purpose. To formulate and characterize a drug-eluting contact lens designed to provide
extended, controlled release of a drug. methods. Prototype contact lenses were created by …
extended, controlled release of a drug. methods. Prototype contact lenses were created by …
24-month phase I/II clinical trial of bimatoprost sustained-release implant (Bimatoprost SR) in glaucoma patients
ER Craven, T Walters, WC Christie, DG Day, RA Lewis… - Drugs, 2020 - Springer
Objective The objective of this study was to evaluate the safety and intraocular pressure
(IOP)-lowering effects over 24 months of biodegradable bimatoprost sustained-release …
(IOP)-lowering effects over 24 months of biodegradable bimatoprost sustained-release …
In vivo performance of a drug-eluting contact lens to treat glaucoma for a month
JB Ciolino, CF Stefanescu, AE Ross, B Salvador-Culla… - Biomaterials, 2014 - Elsevier
For nearly half a century, contact lenses have been proposed as a means of ocular drug
delivery, but achieving controlled drug release has been a significant challenge. We have …
delivery, but achieving controlled drug release has been a significant challenge. We have …