Flowing blood generates a frictional force called shear stress that has major effects on
vascular function. Branches and bends of arteries are exposed to complex blood flow …

A central function of the vascular endothelium is to serve as a barrier between the blood and
the surrounding tissue of the body. At the same time, solutes and cells have to pass the …

Endothelial cells transduce mechanical forces from blood flow into intracellular signals
required for vascular homeostasis. Here we show that endothelial NOTCH1 is responsive to …

While blood vessels play important roles in bone homeostasis and repair, fundamental
aspects of vascular function in the skeletal system remain poorly understood. Here we show …

During animal development, cell-fate-specific changes in gene expression can modify the
material properties of a tissue and drive tissue morphogenesis. While mechanistic insights …

Background: Mutations in PIEZO1 (Piezo type mechanosensitive ion channel component 1)
cause human lymphatic malformations. We have previously uncovered an ORAI1 (ORAI …

The major function of the lymphatic system is to drain interstitial fluid from tissue. Functional
drainage causes increased fluid flow that triggers lymphatic expansion, which is …

Abstract Changes in cell fate and identity are essential for endothelial-to-haematopoietic
transition (EHT), an embryonic process that generates the first adult populations of …

Mechanical force is a determinant of Notch signalling but the mechanism of force detection
and its coupling to Notch are unclear. We propose a role for Piezo1 channels, which are …

Endocardial cells are cardiac endothelial cells that line the interior of the heart tube.
Historically, their contribution to cardiac development has mainly been considered from a …