Oximes have been studied for decades because of their significant roles as
acetylcholinesterase reactivators. Over the last twenty years, a large number of oximes have …

Indirubin is the crucial ingredient of Danggui Longhui Wan and Qing-Dai, traditional
Chinese medicine herbal formulas used for the therapy of chronic myelocytic leukemia in …

Human protozoan diseases represent a serious health problem worldwide, affecting mainly
people in social and economic vulnerability. These diseases have attracted little investment …

Indirubin is the active component of Danggui Longhui Wan, a traditional Chinese medicine
formulation. The encouraging clinical results from the 1980s obtained in chronic myelocytic …

Marine molluscs from the family Muricidae hold great potential for development as a source
of therapeutically useful compounds. Traditionally known for the production of the ancient …

The addition of chalcone and amine components into indirubin-3′-oxime resulted in 15
new derivatives with high yields. Structures of new derivatives were also elucidated through …

As genetic interventions or extended caloric restriction cannot be applied in humans, many
studies have been devoted to the identification of natural products that can prolong …

Introduction: Indirubins are bisindole alkaloids naturally occurring in indigo-bearing plants or
in mollusks from the Muricidae family. They belong to the rather small family of indigoids …

Covering: 1995 to early 2013 This review covers the isolation, chemical structure, biological
activity, structure activity relationships including synthesis of chemical probes, and …

Background Insufficient solubility and stability of bioactive small molecules as well as poor
biocompatibility may cause low bioavailability and are common obstacles in drug …