Multigenerational and transgenerational effects of paternal exposure to drugs of abuse on behavioral and neural function

LR Goldberg, TJ Gould - European Journal of Neuroscience, 2019 - Wiley Online Library
Addictions are highly heritable disorders, with heritability estimates ranging from 39% to
72%. Multiple studies suggest a link between paternal drug abuse and addiction in their …

Bored at home?—A systematic review on the effect of environmental enrichment on the welfare of laboratory rats and mice

P Mieske, U Hobbiesiefken… - Frontiers in Veterinary …, 2022 - frontiersin.org
Boredom is an emotional state that occurs when an individual has nothing to do, is not
interested in the surrounding, and feels dreary and in a monotony. While this condition is …

Environmental enrichment and its influence on rodent offspring and maternal behaviours, a scoping style review of indices of depression and anxiety

JE Sparling, K Barbeau, K Boileau… - … Biochemistry and Behavior, 2020 - Elsevier
Environmental enrichment is a widely used experimental manipulation that consistently
shows measurable effects on rodent behaviour across the lifespan. This scoping review …

A call for replications of addiction research: which studies should we replicate and what constitutes a 'successful'replication?

RM Heirene - Addiction Research & Theory, 2021 - Taylor & Francis
Several prominent researchers in the problem gambling field have recently called for high-
quality replications of existing gambling studies. This call should be extended to the entire …

Paternal morphine self-administration produces object recognition memory deficits in female, but not male offspring

AS Ellis, AB Toussaint, MC Knouse, AS Thomas… - …, 2020 - Springer
Rationale Parental drug use around or before conception can have adverse consequences
for offspring. Historically, this research has focused on the effects of maternal substance use …

Exposure to drugs of abuse induce effects that persist across generations

AM Baratta, RS Rathod, SL Plasil, A Seth… - International review of …, 2021 - Elsevier
Substance use disorders are highly prevalent and continue to be one of the leading causes
of disability in the world. Notably, not all people who use addictive drugs develop a …

Effect of enriched environment during adolescence on spatial learning and memory, and voluntary consumption of morphine in maternally separated rats in adulthood

J Mohammadian, M Najafi… - Developmental …, 2019 - Wiley Online Library
This study was designed to examine the effect of environmental enrichment (EE) during
adolescence on spatial learning and memory and voluntary morphine consumption in …

Paternal exposure to morphine during adolescence induces reward-resistant phenotype to morphine in male offspring

M Azadi, H Azizi, A Haghparast - Brain research bulletin, 2019 - Elsevier
The developing brain is extremely sensitive to drugs during adolescence. The devastating
impacts of opioid abuse in this critical period not only do involve individuals but also are …

Influence of substance use on male reproductive health and offspring outcomes

JO Lo, JC Hedges, WH Chou, KR Tager… - Nature Reviews …, 2024 - nature.com
The prevalence of substance use globally is rising and is highest among men of
reproductive age. In Africa, and South and Central America, cannabis use disorder is most …

Who's your daddy? Behavioral and epigenetic consequences of paternal drug exposure

SJ Nieto, TA Kosten - International Journal of Developmental Neuroscience, 2019 - Elsevier
Substance use disorders (SUDs) reflect genetic and environmental factors. While identifying
reliable genetic variants that predispose individuals to developing SUDs has been …