The accumulation of deficits with increasing age results in a decline in the functional
capacity of multiple organs and systems. These changes can have a significant influence on …

Introduction: The worldwide population is aging, and several age-associated physiological
and pathophysiological changes can affect drug disposition. This is particularly important in …

Individualization of drug therapy requires that the right drug be administered at the correct
dose to patients who are likely to achieve the highest benefit and lowest risk. Female sex …

Beyond their contribution to the metabolism of xenobiotics, cytochrome P450 (CYP)
epoxygenases are actively involved in the metabolism of endogenous substances, like …

Paracetamol is the most commonly used analgesic in older people, and is mainly dosed
according to empirical dosing guidelines. However, the pharmacokinetics and thereby the …

Idiosyncratic drug‐induced liver injury (IDILI) is a significant source of drug recall and acute
liver failure (ALF) in the United States. While current drug development processes …

Metabolic syndrome (MetS) is a complex condition encompassing a constellation of
cardiometabolic abnormalities. Oxylipins are a superfamily of lipid mediators regulating …

Introduction: The number of people with dementia internationally is increasing. Older adults
with dementia are prescribed multiple medications, both to treat dementia symptoms and to …

In high dosages, acetaminophen (APAP) can cause severe liver damage, but susceptibility
to liver failure varies across individuals and is influenced by factors such as health status …

Therapeutic Reviews aim to provide essential independent information for health
professionals about drugs used in palliative and hospice care. Additional content is …